An anti-senescence nanoplatform and its underlying mechanism

该项目将通过结合生物材料、细胞和分子生物学以及工程学，汇集互补的专业知识和技能，开发一种新型的纳米生物材料抗衰老平台，并深入了解其潜在机制。衰老的潜在机制仍然难以捉摸，具有抗衰老特性的骨替代品尚未被探索，并成为骨再生领域日益增长的兴趣。该项目将开发一个定义明确、高效的纳米材料平台，将纳米表面特征和化学成分最佳地结合起来，用于细胞再生，并将使跨学科对衰老再生机制的理解达到前所未有的深度。

The project will bring together complementary expertise and skills by combining biomaterials, cell and molecular biology, and engineering, to develop a novel nano-biomaterial platform for anti-senescence and gain an in-depth understanding of its underlying mechanisms. The underlying mechanisms of senescence remain elusive and bone substitutes with anti-senescence property have not been explored and becoming a growing field of interest in bone regeneration. The project will develop a well-defined and efficient nanomaterial platform with optimal combination of nano-surface features and chemistry for cell rejuvenation, and it will give unprecedented depth of interdisciplinary understanding of senescence rejuvenation mechanisms.