An anti-senescence nanoplatform and its underlying mechanism

抗衰老纳米平台及其潜在机制

• 批准号: DP220102876
• 负责人: Prof Hala Zreiqat
• 金额: $ 36.34万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220102876
• 关键词: anti; senescence; nanoplatform; its; underlying

The project will bring together complementary expertise and skills by combining biomaterials, cell and molecular biology, and engineering, to develop a novel nano-biomaterial platform for anti-senescence and gain an in-depth understanding of its underlying mechanisms. The underlying mechanisms of senescence remain elusive and bone substitutes with anti-senescence property have not been explored and becoming a growing field of interest in bone regeneration. The project will develop a well-defined and efficient nanomaterial platform with optimal combination of nano-surface features and chemistry for cell rejuvenation, and it will give unprecedented depth of interdisciplinary understanding of senescence rejuvenation mechanisms.

该项目将通过将生物材料、细胞分子生物学和工程学结合起来，将互补的专业知识和技能结合在一起，开发一种新型的纳米生物材料抗衰老平台，并深入了解其潜在机制。衰老的潜在机制仍不清楚，具有抗衰老特性的骨替代材料尚未被探索，成为骨再生研究的一个日益重要的领域。该项目将开发一个定义明确、高效的纳米材料平台，将纳米表面特征和化学的最佳组合用于细胞再生，并将对衰老再生机制的跨学科理解提供前所未有的深度。