IDR-Collaborative: Quantitative 3D Optical Tomographic Microscopy for Lung Cancer Diagnosis

1014813 reev1该团队正在开发的一种显微镜工具将首次实现细胞及其细胞器的定量吸收和荧光三维成像，这可以与疾病诊断的临床标准相关联。该项目在两种重要的对比模式下开发了3D定量显微镜的新领域，弥合了临床诊断和医学研究之间的差距。此外，在一项独特的合作中，用于疾病诊断的定量CT成像的3D图像处理技术正被应用于显微镜。细胞生物学的教科书将细胞描绘成平面的二维特征。如果疾病诊断是3D的，对疾病的发病更加定量和敏感，那么这些教科书可能会改变，更准确地代表细胞解剖。由于真正的3D显微镜的进步，教授学生细胞结构和功能可能会发生重大变化。为细胞学家和分子生物学家提供定量工具将有助于更早地诊断肺癌等致命疾病，并提高对疾病机制的了解。

1014813ReevesA microscopic tool being developed by this team will allow quantitative absorption and fluorescence 3D imaging of cells and their organelles which can be correlated to the clinical standards of disease diagnosis for the first time. This project develops new fields of 3D quantitative microscopy in two important contrast modes that bridge a gap between clinical diagnosis and medical research. In addition, the technology of 3D image processing from quantitative CT imaging for disease diagnosis is being applied to microscopy in a unique collaboration.Textbooks of cell biology depict a cell as flat with two-dimensional features. If disease diagnosis is 3D and more quantitative and sensitive to disease onset, then these textbooks will likely change to more accurately represent the cell anatomy. Teaching students on cellular structures and functions may be significantly changed due to advancements of true 3D microscopy. Providing cytologists and molecular biologists with quantification tools will result in earlier diagnosis of lethal diseases like lung cancer and improved understanding of the disease mechanisms.