Experimental studies of learning evolution: the role of reliability and uncertainty
Experimental studies of learning evolution: the role of reliability and uncertainty
批准号:
1021183
负责人:
David Stephens
金额:
$57.5万
依托单位国家:
美国
项目类别:
Continuing Grant
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-09-15 至 2015-08-31
中文摘要
这个项目将研究自然选择如何塑造动物的学习能力。它将在许多代人之间操纵简化的“环境”的两个理论上重要的属性。该项目将询问这些环境差异是否会导致果蝇(果蝇)种群的学习能力增强或降低。学习是人类和非人类行为的基本机制,研究人员长期以来一直认为,不断变化的环境选择学习能力。然而,像这样的说法很难检验,因为很难衡量或控制随着进化时间的推移而产生的“环境变化”。这项研究将使用新技术来控制多代人的环境变化,并将测试关于变化属性的假设,这些假设既有利于学习能力,也反对学习能力。预计该项目将产生不同程度学习能力的果蝇(果蝇)品系,这些品系将有助于进一步研究学习能力的生理基础。出于几个实际原因,理解学习能力的差异是很重要的。首先,它将帮助我们在不断变化的环境中(例如,在不断变化的气候中)管理种群,并加深我们对人类学习能力差异的理解。该项目将为至少九名本科生提供实践研究经验。
英文摘要
This project will study how natural selection shapes animal learning abilities. It will manipulate two theoretically important attributes of a simplified "environment" across many generations. The project will ask whether these environmental differences lead to enhanced or reduced learning abilities in populations of the fruit fly (Drosophila). Learning is a basic mechanism of both human and non-human behavior, and investigators have long believed that changing environments select for learning abilities. It has been difficult, however, to test claims like this because it is hard to measure or control "environmental change" over evolutionary time. This research will use novel techniques to control environmental change over many generations and it will test hypotheses about the properties of change that select both for and against learning abilities. It is expected that this project will generate lines of fruit flies (Drosophila) with varying degrees of learning ability, and that these lines of flies will be useful for further study of the physiological basis of learning ability. It is important to understand variation in learning abilities for several practical reasons. First, it will help us manage populations in changing environments (for example, in changing climates) and it furthers our understanding of variation in human learning abilities. This project will provide hands on research experience for at least nine undergraduate students.
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会议论文
Functional interplay of ciliary trafficking complexes and motor proteins.
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批准号:BB/S013024/1
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项目类别:Research Grant
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资助金额:$59.61万
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财政年份:2019
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负责人:David Stephens
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依托单位:
High-resolution imaging and time-resolved proteomic profiling of COPII-dependent procollagen packaging.
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批准号:MR/P000177/1
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项目类别:Research Grant
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资助金额:$58.94万
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财政年份:2016
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负责人:David Stephens
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依托单位:
The dynein-2 microtubule motor
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批准号:BB/N000420/1
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项目类别:Research Grant
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资助金额:$47.83万
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财政年份:2016
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负责人:David Stephens
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依托单位:
The Golgi apparatus as an initiator of ciliogenesis
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批准号:MR/K018019/1
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项目类别:Research Grant
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资助金额:$46.95万
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财政年份:2013
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负责人:David Stephens
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依托单位:
Photo-oxidation and cryofluorescence for Correlative Light Electron Microscopy.
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批准号:BB/L014181/1
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项目类别:Research Grant
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资助金额:$82.03万
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财政年份:2013
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负责人:David Stephens
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依托单位:
Subversion of ER exit sites for FMDV replication
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批准号:BB/J00474X/1
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项目类别:Research Grant
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资助金额:$1.47万
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财政年份:2012
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负责人:David Stephens
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依托单位:
Mechanism and function of organization of secretory cargo export from the endoplasmic reticulum.
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批准号:MR/J000604/1
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项目类别:Research Grant
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资助金额:$41.54万
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财政年份:2012
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负责人:David Stephens
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依托单位:
GABA-A receptors in accumbens neural circuits underlying drug abuse: novel targets for treatment?
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批准号:G1000008/1
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项目类别:Research Grant
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资助金额:$127.42万
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财政年份:2010
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负责人:David Stephens
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依托单位:
The role of microtubule motor proteins in cargo sorting
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批准号:G0801848/1
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项目类别:Research Grant
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资助金额:$58.8万
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财政年份:2009
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负责人:David Stephens
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依托单位:
Selective chemical intervention in membrane trafficking - designing interfacial inhibitors specific to Arf1/Arf-GEF complexes
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批准号:BB/E012450/1
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项目类别:Research Grant
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资助金额:$35.91万
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财政年份:2007
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负责人:David Stephens
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依托单位:
The role of Sec16p in the organization and function of mammalian ER export sites.
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批准号:BB/E019633/1
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项目类别:Research Grant
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资助金额:$38.29万
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财政年份:2007
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负责人:David Stephens
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依托单位:
Involvement of alpha2 subunit-containing GABAA receptors in circuits underlying drug abuse
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批准号:G0600874/1
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项目类别:Research Grant
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资助金额:$42.02万
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财政年份:2007
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负责人:David Stephens
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依托单位:
Animal Impulsivity: Discounting or Ecological Rationality
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批准号:0235261
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项目类别:Continuing Grant
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资助金额:$34.0万
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财政年份:2003
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负责人:David Stephens
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依托单位:
SGER: The Evolutionary Genetics of Avian Choice Behavior
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批准号:0130027
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项目类别:Standard Grant
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资助金额:$3.45万
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财政年份:2001
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负责人:David Stephens
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依托单位:
CONF: International Conference on Foraging Behavior: Nervous Systems to Ecosystems, July 22 - 24, 1998 in Santa Cruz, CA
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批准号:9802697
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项目类别:Standard Grant
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资助金额:$0.4万
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财政年份:1998
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负责人:David Stephens
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依托单位:
Cooperation, Altruism, and Self-control
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批准号:9896102
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项目类别:Continuing Grant
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资助金额:$7.02万
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财政年份:1997
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负责人:David Stephens
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依托单位:
Cooperation, Altruism, and Self-control
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批准号:9507668
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项目类别:Continuing Grant
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资助金额:$21.61万
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财政年份:1995
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负责人:David Stephens
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依托单位:
PYI: Theoretical and Experimental Studies of Animal FeedingBehavior
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批准号:8958228
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项目类别:Continuing Grant
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资助金额:$14.38万
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财政年份:1989
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负责人:David Stephens
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依托单位:
PRF: Incomplete Information in Sex Allocation Theory
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批准号:8411495
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项目类别:Fellowship Award
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资助金额:$5.28万
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财政年份:1984
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负责人:David Stephens
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依托单位:
国内基金
海外基金
脂滴聚集型小胶质细胞介导的髓鞘病变促进小鼠抑郁样行为及其机制研究
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批准号:82371528
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项目类别:面上项目
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资助金额:49.00万元
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批准年份:2023
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负责人:李媛
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依托单位:
星形胶质细胞介导的髓鞘吞噬参与慢性脑低灌注白质损伤的机制研究
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批准号:82371307
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项目类别:面上项目
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资助金额:49.00万元
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批准年份:2023
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负责人:汤耀辉
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依托单位: