Arabidopsis 2010: Simultaneous Genome Wide Association Mapping in Plant Host and Pathogen

长期以来，对传染病的研究要么是通过对病原体的调查，要么是通过对宿主的调查。然而，将疾病视为来自两种生物体的基因组如何相互作用的结果更为恰当，特别是对于在从农业到商业等众多经济领域造成重大和持续损失的地方病。该项目将开始研究整个宿主和病原体基因组中存在的遗传多样性如何同时相互作用以控制感染结果。利用对一种具有多样性和破坏性的植物病原体灰霉菌（Botrytis cinerea）和模式植物拟南芥（Arabidopsis thaliana）的下一代测序，该项目将专门确定多样性网络，使一种特有植物疾病能够克服多样性和波动的植物防御。这将为地方病如何演变提供独特的见解，并为如何应对这种演变提供思路。此外，该项目将为如何对复杂表型（如疾病）进行全基因组关联研究提供新的见解和指导。该项目将涉及生物学、遗传学、生物化学和计算基因组学的高度整合，所有这些都在一个实验室内，这将提供一个最佳的平台，培养未来的科学家，他们可以充分利用所有基因组技术，更有效地解决社会紧迫的问题和问题。

Infectious disease has long been studied either via investigations into the pathogen or host. However, it is more appropriate to consider disease as the outcome of how the genomes from two organisms interact, especially for endemic diseases which cause significant and persistent losses in numerous economic arenas ranging from agriculture to business. This project will begin one of the first investigations into how the genetic diversity present in entire host and pathogen genomes simultaneously interact to control the infection outcome. Using next generation sequencing with a diverse and destructive plant pathogen, Botrytis cinerea (grey mold), and a model plant, Arabidopsis thaliana, this project will specifically identify diversity networks that enable an endemic plant disease to overcome diverse and fluctuating plant defenses. This will provide unique insight into how endemic diseases may evolve and provide ideas of how to counter this evolution. Additionally, this project will provide novel insights and guidance into how to conduct genome wide association studies on complex phenotypes such as disease. The project will involve a highly integrative combination of biology, genetics, biochemistry and computational genomics all within a single laboratory that will provide an optimal platform in which to train future scientists that can take full advantage of all genomic technologies to more efficiently solve societies pressing questions and problems.