MRI: Development of an NMR Console for the 36 T Series Hybrid

MRI：为 36 T 系列 Hybrid 开发 NMR 控制台

• 批准号: 1039938
• 负责人: William Brey
• 金额: $ 130万
• 依托单位: Florida State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-10-01 至 2016-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1039938&HistoricalAwards=false
• 关键词: MRI; Development; NMR; Console; 36

Technical AbstractThe development of a nuclear magnetic resonance (NMR) console is essential to carry out the scientific program for which the Series Hybrid magnet at the NHMFL was funded. The proposed console together with the new high homogeneity magnet will increase the available field for high-homogeneity NMR from 23 to 36 T and provide important scientific opportunities. For the first time, scientists will be able to obtain chemically resolved spectra of strongly broadened isotopes. These quadrupolar nuclei, which comprise most of the periodic table and which are important for catalysts, porous materials, batteries and fuel cells, are sensitive to the molecular electric field but are impractical to study by lower field NMR due to their extreme line broadening. In addition, more than 25% of all biological macromolecules contain metals. These nuclei will also be newly accessible to NMR. The quadrupolar species 17^O and 14^N are important sites of functional activity, and will be directly observable at 36 T. The console will also facilitate development of new techniques for 1H NMR analysis of solid materials, in which the resonance lines are broadened by large spin interactions. By combining very high field and very fast sample spinning, 1H solid state NMR spectroscopy promises to become a very sensitive tool with adequate spectral resolution for scientific challenges, ranging from functionalized silicate surfaces to macromolecular studies. The user facility, providing high quality spectroscopy at up to 36 T, will allow the United States to stay at the forefront of solid state magnetic resonance for the foreseeable future.Non-Technical AbstractAnalysis of the weak magnetic signals from hydrogen led to the revolution in medicine that we know as MRI, or Magnetic Resonance Imaging. Past developments in MRI and its first cousin nuclear magnetic resonance (NMR), which uses the same signals for chemical analysis, have been significant enough to garner four Nobel prizes. And yet, of all the elements, only a handful can be observed in conventional MRI scanners and NMR spectrometers. Other elements, including most of those important to science and medicine, produce only poorly resolved signals in the magnets typically available in laboratories. The proposed NMR/MRI scanner, together with a strong new NSF-supported magnet already under construction, will greatly extend the range of elements that can be studied by NMR to include most of the periodic table. Analyzing the chemical configuration of these elements has the potential to improve many areas of life, such as the development of batteries and fuel cells, and of new catalysts. The spectrometer is essential to carry out the scientific program of the NSF-funded series hybrid magnet, a new powered research magnet that uses less energy, and has a more uniform and constant field than previous powered magnets. The innovative magnet and NMR spectrometer will become part of the Mag Lab's user program, allowing the U.S. to stay at the forefront of magnetic resonance research for the foreseeable future.

技术摘要核磁共振（NMR）控制台的发展是必不可少的进行科学计划的系列混合磁体在NHMFL的资助。 拟议的控制台与新的高均匀性磁体一起将高均匀性NMR的可用场从23 T增加到36 T，并提供重要的科学机会。 科学家们将首次能够获得强增宽同位素的化学分辨光谱。 这些四极核，其中包括大部分的周期表，这是重要的催化剂，多孔材料，电池和燃料电池，是敏感的分子电场，但不切实际的研究低场核磁共振由于其极端线加宽。 此外，超过25%的生物大分子含有金属。 这些核也将是NMR新的可及的。 四极核素17 ^O和14 ^N是重要的功能活性位点，在36 T下可直接观察到。 该控制台还将促进固体材料1H NMR分析新技术的开发，其中共振线因大自旋相互作用而加宽。 通过结合非常高的磁场和非常快的样品旋转，1H固态NMR光谱有望成为一种非常灵敏的工具，具有足够的光谱分辨率，可用于从功能化硅酸盐表面到大分子研究的科学挑战。 用户设备，提供高品质的光谱在高达36 T，将使美国留在最前沿的固态磁共振在可预见的future.Non-Technical AbstractAnalysis弱磁信号从氢导致了医学革命，我们知道的MRI，或磁共振成像。 核磁共振成像（MRI）及其近亲核磁共振（NMR）的过去发展，使用相同的信号进行化学分析，已经足够重要，足以获得四项诺贝尔奖。 然而，在所有元素中，只有少数可以在传统的MRI扫描仪和NMR光谱仪中观察到。 其他元素，包括大多数对科学和医学很重要的元素，在实验室通常可用的磁铁中只能产生分辨率很差的信号。 拟议中的NMR/MRI扫描仪，加上一个强大的新的NSF支持的磁铁已经在建设中，将大大扩展可以通过NMR研究的元素的范围，包括大多数元素周期表。 分析这些元素的化学结构有可能改善生活的许多领域，例如电池和燃料电池的开发以及新催化剂的开发。 光谱仪对于执行NSF资助的系列混合磁体的科学计划至关重要，这是一种新的动力研究磁体，使用更少的能量，并且具有比以前的动力磁体更均匀和恒定的磁场。 创新的磁体和核磁共振光谱仪将成为Mag实验室用户计划的一部分，使美国在可预见的未来保持在磁共振研究的最前沿。