MRI: Development of an NMR Console for the 36 T Series Hybrid

技术摘要：核磁共振控制台的研制是国家核磁共振实验室研制系列混合磁体的科研项目的必要条件。该控制台与新的高均匀性磁体将使高均匀性核磁共振的可用场强从23 T增加到36 T，并提供重要的科学机会。科学家们将首次能够获得强展宽同位素的化学分辨光谱。这些四极核构成了元素周期表的大部分，对催化剂、多孔材料、电池和燃料电池都很重要，它们对分子电场很敏感，但由于它们的谱线极宽，用低场核磁共振研究是不切实际的。此外，超过25%的生物大分子含有金属。这些原子核也将是新的核磁共振。四极性物质17^O和14^N是功能活性的重要位点，将在36 t时直接观察到。该控制台还将促进固体材料1H NMR分析新技术的发展，其中共振线被大自旋相互作用拓宽。通过结合非常高的场和非常快的样品旋转，1H固态核磁共振波谱有望成为一个非常敏感的工具，具有足够的光谱分辨率，用于科学挑战，从功能化硅酸盐表面到大分子研究。该用户设施提供高达36 T的高质量光谱，将使美国在可预见的未来保持在固态磁共振的前沿。对氢发出的弱磁信号的分析导致了医学上的革命，即我们所知的MRI，或磁共振成像。核磁共振成像（MRI）和它的“近亲”核磁共振（NMR）使用相同的信号进行化学分析，其过去的发展已经足以获得四次诺贝尔奖。然而，在所有的元素中，只有少数可以在传统的核磁共振扫描仪和核磁共振光谱仪中观察到。其他元素，包括大多数对科学和医学很重要的元素，在实验室中通常可用的磁体中只产生分辨率很差的信号。拟议的核磁共振/核磁共振扫描仪，连同一个已经在建设中的强大的新的nsf支持的磁铁，将极大地扩展核磁共振可以研究的元素范围，包括大多数元素周期表。分析这些元素的化学结构有可能改善生活的许多领域，例如电池和燃料电池的发展，以及新的催化剂。该光谱仪对于执行美国国家科学基金会资助的系列混合磁体的科学计划至关重要，这是一种新的动力研究磁体，使用更少的能量，并且比以前的动力磁体具有更均匀和恒定的磁场。创新的磁体和核磁共振光谱仪将成为Mag实验室用户计划的一部分，使美国在可预见的未来保持在磁共振研究的前沿。

Technical AbstractThe development of a nuclear magnetic resonance (NMR) console is essential to carry out the scientific program for which the Series Hybrid magnet at the NHMFL was funded. The proposed console together with the new high homogeneity magnet will increase the available field for high-homogeneity NMR from 23 to 36 T and provide important scientific opportunities. For the first time, scientists will be able to obtain chemically resolved spectra of strongly broadened isotopes. These quadrupolar nuclei, which comprise most of the periodic table and which are important for catalysts, porous materials, batteries and fuel cells, are sensitive to the molecular electric field but are impractical to study by lower field NMR due to their extreme line broadening. In addition, more than 25% of all biological macromolecules contain metals. These nuclei will also be newly accessible to NMR. The quadrupolar species 17^O and 14^N are important sites of functional activity, and will be directly observable at 36 T. The console will also facilitate development of new techniques for 1H NMR analysis of solid materials, in which the resonance lines are broadened by large spin interactions. By combining very high field and very fast sample spinning, 1H solid state NMR spectroscopy promises to become a very sensitive tool with adequate spectral resolution for scientific challenges, ranging from functionalized silicate surfaces to macromolecular studies. The user facility, providing high quality spectroscopy at up to 36 T, will allow the United States to stay at the forefront of solid state magnetic resonance for the foreseeable future.Non-Technical AbstractAnalysis of the weak magnetic signals from hydrogen led to the revolution in medicine that we know as MRI, or Magnetic Resonance Imaging. Past developments in MRI and its first cousin nuclear magnetic resonance (NMR), which uses the same signals for chemical analysis, have been significant enough to garner four Nobel prizes. And yet, of all the elements, only a handful can be observed in conventional MRI scanners and NMR spectrometers. Other elements, including most of those important to science and medicine, produce only poorly resolved signals in the magnets typically available in laboratories. The proposed NMR/MRI scanner, together with a strong new NSF-supported magnet already under construction, will greatly extend the range of elements that can be studied by NMR to include most of the periodic table. Analyzing the chemical configuration of these elements has the potential to improve many areas of life, such as the development of batteries and fuel cells, and of new catalysts. The spectrometer is essential to carry out the scientific program of the NSF-funded series hybrid magnet, a new powered research magnet that uses less energy, and has a more uniform and constant field than previous powered magnets. The innovative magnet and NMR spectrometer will become part of the Mag Lab's user program, allowing the U.S. to stay at the forefront of magnetic resonance research for the foreseeable future.