Dynamics of cell contacts during cell intercalation in germband extension of Drosophila

果蝇种带延伸中细胞插入过程中细胞接触的动态

• 批准号: 200512160
• 负责人: Professor Dr. Jörg Großhans
• 金额: --
• 依托单位: Campus Institut für Dynamik biologischer Netzwerke (CIDBN)
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/200512160?language=en
• 关键词: Dynamics; cell; contacts; during; intercalation

Many morphogenetic movements during development depend on cell intercalation, when cells within a tissue exchange their neighbours. During this process cell contacts are weakened to slide along their neighbors, while at the same time they have to remain sufficiently strong to maintain the integrity of the tissue. In this project, directed cell intercalation during germband elongation in Drosophila em-bryogenesis is investigated. Specifically the role of newly synthesised E-Cadherin protein and proc-essing of the protein within the endoplasmic reticulum for the formation of new cell contacts during neighbour exchanges will be analysed. In addition we will investigate to which degree the cells within the tissue form a coordinated network, i. e. whether the mechanics of a cell influences the behaviour of its next and further distant neighbours and to which degree this mechanism is responsible for coor-dination.

发育过程中的许多形态发生运动取决于细胞嵌入，即组织内的细胞交换它们的邻居。在此过程中，细胞接触被削弱以沿着它们的邻居滑动，而同时它们必须保持足够的强度以保持组织的完整性。本项目研究了果蝇胚胎发育中胚带延伸过程中的定向细胞插入。特别是新合成的E-Cadherin蛋白的作用和处理的蛋白质内的内质网形成新的细胞接触在邻居的交流将进行分析。此外，我们将研究组织内的细胞在何种程度上形成了一个协调的网络，即。e.细胞的机制是否影响其下一个和更远的邻居的行为，以及这种机制在多大程度上负责协调。