Regulation and function of actin nucleation in the early Drosophila embryo

早期果蝇胚胎肌动蛋白成核的调控和功能

• 批准号: 170435737
• 负责人: Professor Dr. Jörg Großhans
• 金额: --
• 依托单位: Arbeitsgruppe Entwicklungsgenetik
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/170435737?language=en
• 关键词: Regulation; function; actin; nucleation; early

In the early embryo of Drosophila, actin filaments are dynamically organised in discrete structures that are controlled by actin nucleator complexes. Given the fast development and the experimental tractablility of the embryos, it is possible to correlate structure and function and test the function of actin structures in visible morphogenetic processes, such as membrane invagination, nuclear positioning, cell shapes and cell rearrangement. Here we investigate the function and regulation of the actin nucleator Diaphanous in plasma membrane organisation during cellularisation and germband extention during early embryonic development of Drosophila. Specifically, we investigate how Diaphanous is involved in defining and maintaining distinct membrane domains.

在果蝇的早期胚胎中，肌动蛋白细丝动态地组织在离散的结构中，这些结构由肌动蛋白核仁复合体控制。鉴于胚胎的快速发育和实验易操纵性，有可能将结构和功能联系起来，并测试肌动蛋白结构在可见形态发生过程中的功能，如膜内陷、核定位、细胞形状和细胞重排。在这里，我们研究了在果蝇早期胚胎发育的细胞化和生殖带延伸过程中，质膜组织中透明的肌动蛋白核蛋白的功能和调节。具体地说，我们调查透明蛋白是如何参与定义和维持不同的膜域的。