CAREER: Molecular Recognition of Anions with Novel Macrocyclic Chemosensors

职业：用新型大环化学传感器对阴离子进行分子识别

• 批准号: 1056927
• 负责人: Md. Alamgir Hossain
• 金额: $ 40万
• 依托单位: Jackson State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-15 至 2016-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1056927&HistoricalAwards=false
• 关键词: CAREER; Molecular; Recognition; Anions; Novel

This CAREER award by the Macromolecular, Supramolecular and Nanochemistry Program and the Chemical Measurement and Imaging Program of the Chemistry Division supports research and educational activities of Professor Md. Alamgir Hossain of the Department of Chemistry and Biochemistry at Jackson State University to develop new macrocyclic chemosensors for the colorimetric detection and selective recognition of environmentally and biologically important anions. The approach is to use cyclic polyaza-receptors as frameworks for the construction of three selected series of chemosensors including (i) indicator-spacer receptors, (ii) dinuclear metal complexes with redox switches, and (iii) indicator-displacement assays. The ultimate goal is aimed at deeper understanding of the factors responsible for selective anion recognition at the molecular level. This work advances the field of anion recognition chemistry by introducing a new series of architecturally assembled chemosensors. The program involves graduate and undergraduate students, particularly underrepresented minorities, in interdisciplinary research and education.The educational activities are to promote early involvement of high school and undergraduate students in science. During summer months, this project provides opportunities to engage high school students and teachers in meaningful chemical research. Developing international and interdisciplinary collaborations are key components of this CAREER project, which advance students' research capability and broaden their education. In addition, an outreach program 'Chemistry in Nature' is designed to make chemistry interesting and understandable to K-12 students. Students working in the group of Professor Hossain are expected to actively participate in regional and national meetings for presenting their research to the broader scientific community, and to publish results in widely circulated and respected journals.

这个职业奖的高分子，超分子和纳米化学计划和化学测量和成像计划的化学部支持研究和教育活动的教授医学博士。杰克逊州立大学化学和生物化学系的Alamgir Hossain开发新的大环化学传感器，用于比色检测和选择性识别环境和生物学上重要的阴离子。 该方法是使用环状多氮受体作为框架，用于构建三个选定的系列的化学传感器，包括（i）指示剂间隔受体，（ii）双核金属配合物与氧化还原开关，和（iii）指示剂置换试验。 最终目标是在分子水平上更深入地了解负责选择性阴离子识别的因素。 这项工作通过引入一系列新的结构组装化学传感器推进了阴离子识别化学领域。该计划涉及研究生和本科生，特别是代表性不足的少数民族，在跨学科的研究和教育。教育活动是为了促进高中和本科生在科学的早期参与。在夏季的几个月里，这个项目提供了机会，让高中学生和教师参与有意义的化学研究。 发展国际和跨学科合作是这个职业项目的关键组成部分，它提高了学生的研究能力，扩大了他们的教育。 此外，一个外展计划“自然化学”的目的是使化学有趣和理解K-12学生。在Hossain教授小组工作的学生将积极参加区域和国家会议，向更广泛的科学界介绍他们的研究，并在广泛发行和受人尊敬的期刊上发表成果。