SENSORS FOR ANIONS OF ENVIRONMENTAL AND BIOMEDICAL RELEVANCE

环境和生物医学相关阴离子传感器

• 批准号: 7959216
• 负责人: Md. Alamgir Hossain
• 金额: $ 12.8万
• 依托单位: JACKSON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959216
• 关键词: Anions; Apical; Binding; Biological; Bromides; Chloride Ion; Chlorides; Complex; Computer Retrieval of Information on Scientific Projects Database; Encapsulated; Environmental Health; Funding; Grant; Inorganic Sulfates; Institution; Investigation; Iodides; Ligand Binding; Ligands; Molecular Conformation; Nitrates; Nitrogen; Oxygen; Property; Protons; Research; Research Personnel; Resources; Side; Solutions; Source; Structure; Techniques; Thiophenes; Time; Titrations; United States National Institutes of Health; Unspecified or Sulfate Ion Sulfates; base; design; receptor; sensor; solid solution; solid state

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project involves the design and synthesis of receptors for anions of environmental and biological importance specifically. Polyazamacrocycles as receptors and oxoanions and halides were the focus during the first year. During this time, three approaches ware employed: (i) design, synthesis, and characterization of receptors, (ii) examination of the binding capabilities of the synthesized compounds for anions in solution by NMR titration technique, and (iii) investigation of solid state structures of the host-guest complexes. A thiophene based azacryptand has been synthesized, and its anion binding properties have been studied in both solid and solution states. Crystallographic studies indicate that the ligand binds one chloride or three nitrates with an in-in conformation of the bridgehead amino protons. In the chloride complex, the encapsulated anion sits in the cavity with N++++Cl¿ distance 3.10(1) ¿, whereas, for the nitrate complex, the three anions are located in three side pockets, and are bridged through one oxygen with the two in-in protons on the apical nitrogen with an average distance of N+++O of 3.238 ¿. The NMR titrations were performed for chloride, bromide, iodide, nitrate and sulfate. Results indicated that the ligand effectively binds these anions ranging from 4,000 to 100,000 M-1. Three other ligands were also synthesized that are planed to study for anions in both solution and solid states. These compounds are currently being investigated by Dr. Clement G. Yedjou (collobaroator of this project) for cytoxicity studies.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目涉及的设计和合成的阴离子的环境和生物的重要性，具体的受体。多氮大环化合物作为受体，含氧阴离子和卤化物是第一年的重点。在此期间，采用了三种方法：（i）受体的设计，合成和表征，（ii）通过NMR滴定技术检测合成化合物对溶液中阴离子的结合能力，以及（iii）研究主客体复合物的固态结构。 合成了一种噻吩基氮杂环戊二烯并，研究了其在固态和溶液状态下的阴离子结合性能。 晶体学研究表明，配体结合一个氯离子或三个硝酸盐与在构象的桥头氨基质子。在氯化物络合物中，被包裹的阴离子位于空腔中，N+Cl，而对于硝酸盐络合物，三个阴离子位于三个侧袋中，并通过一个氧与顶端氮上的两个in-in质子桥接，N+O的平均距离为3.238。 对氯化物、溴化物、碘化物、硝酸盐和硫酸盐进行NMR滴定。结果表明，配体有效地结合这些阴离子的范围从4，000至100，000 M-1。还合成了其他三种配体，计划用于研究溶液和固体状态下的阴离子。这些化合物目前正由Clement G.用于细胞毒性研究的Yedjou（本项目的协调员）。