Common neural substrates for uncertainty processing in decision-making and perception

决策和感知中不确定性处理的常见神经基质

• 批准号: 200569870
• 负责人: Professor Dr. Wolfgang Einhäuser-Treyer
• 金额: --
• 依托单位: Department of Economics
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/200569870?language=en
• 关键词: Common; neural; substrates; uncertainty; processing

Most decisions in life are based on incomplete information and have uncertain consequences. To successfully cope with real-life situations, the nervous System has to estimate, represent and eventually resolve uncertainty at various levels. Here we | propose to test the hypothesis of a common neural origin for two distinct forms of l uncertainty: perceptual and cognitive uncertainty. Perceptual uncertainty arises from the ambiguity in the mapping from complex Stimuli to sensory Signals. Cognitive uncertainty arises from the stochastic nature of outcomes (rewards, penalties) associated with actions. Perceptual uncertainty finds a prime testbed in rivalry of multi-stable figures (e.g., the Necker cube): although two or more interpretations of the Stimulus are equally consistent with input and prior knowledge, the visual System at any point in time resolves this uncertainty, such that the observer experiences a unique percept. Cognitive uncertainty is readily introduced by gambling paradigms, such äs coin flips. By combining these paradigms - rivalry and gambling - the proposed project addresses the joint basis of both forms of uncertainty: how do perceptual and cognitive uncertainty interact behaviourally and neurally to affect decision-making?

生活中的大多数决定都是基于不完整的信息，并且具有不确定的后果。为了成功地科普现实生活中的情况，神经系统必须估计，表示并最终解决各种级别的不确定性。这里我们|建议测试两种不同形式的L不确定性的共同神经起源的假设：感知和认知的不确定性。感知的不确定性源于从复杂刺激到感觉信号的映射中的模糊性。认知不确定性源于与行为相关的结果（奖励、惩罚）的随机性。感知不确定性在多稳定数字的竞争中找到了一个主要的测试平台（例如，Necker cube）：虽然两个或多个刺激的解释与输入和先验知识同样一致，但视觉系统在任何时间点都解决了这种不确定性，使得观察者体验到独特的感知。认知不确定性很容易被赌博范式引入，比如掷硬币。通过结合这些范例-竞争和赌博-拟议的项目解决了两种形式的不确定性的共同基础：感知和认知的不确定性如何在行为和神经上相互作用，以影响决策？

项目成果

Fronto-insula network activity explains emotional dysfunctions in juvenile myoclonic epilepsy: Combined evidence from pupillometry and fMRI

• DOI: 10.1016/j.cortex.2015.01.018
• 发表时间: 2015-04
• 期刊: Cortex
• 影响因子: 3.6
• 作者: F. Paulus;S. Krach;Marius Blanke;Christine Roth;M. Belke;J. Sommer;Laura Müller-Pinzler;K. Menzler;A. Jansen;F. Rosenow;F. Bremmer;W. Einhäuser;S. Knake

Evidence from pupillometry and fMRI indicates reduced neural response during vicarious social pain but not physical pain in autism

来自瞳孔测量和功能磁共振成像的证据表明，自闭症患者在替代性社交疼痛期间神经反应减少，但身体疼痛却没有减少

• DOI: 10.1002/hbm.22949
• 发表时间: 2015
• 期刊: Human Brain Mapping
• 影响因子: 4.8
• 作者: Kamp-Becker;Einhäuser;Sommer;Frässle;Jansen;Rademacher;Müller-Pinzler;Gazzola;Paulus
• 通讯作者: Paulus