EAGER: Drug Delivery Micro-device for Age-related Macular Degeneration

EAGER：用于治疗年龄相关性黄斑变性的微型药物输送装置

• 批准号: 1058067
• 负责人: Ramana Pidaparti
• 金额: $ 12.92万
• 依托单位: Virginia Commonwealth University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-15 至 2014-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1058067&HistoricalAwards=false
• 关键词: EAGER; Drug; Delivery; Micro; device

The objective of this EAGER grant is to investigate the feasibility and assess the integrity of the implantable device design through computational simulations and optimizing the design for a specific flow rate and delivery time. This objective will be accomplished by implementing the following tasks: (i) Develop design concepts and conduct computational simulations through nano-channel arrays of varying length, height and width, and simulate the drug release kinetics for several candidate drug molecules; and (ii) Optimize the design for specific flow rate and delivery time. Based on the optimized design, a prototype model will be explored. This approach of using computations and design optimization for drug device design and integrity has never been examined for AMD devices due to challenges in size and extended delivery time.Intellectual meritThis project is a high-risk and high payoff and will provide a fundamental understanding of the physical and mechanical interactions through nano-channels of the drug delivery design and will provide valuable scientific insights into integration characteristics and implantable drug delivery devices. Investigating the design integrity and integration of implantable devices for AMD such as the one proposed in this EAGER project will help reduce the costs and risks associated with frequent injections and promote delivering the drug in a controlled manner and in the required amounts for treating AMD disease.Broader impactsThis project will design and develop a novel implantable drug delivery device incorporating nano-channels with controlled drug kinetics and delivery time for treating AMD, and thereby benefit society at large. This project will provide undergraduate and graduate students with multidisciplinary knowledge and training related to drug delivery devices, computational studies and optimization. The research results will be integrated into courses the PI?s teach in the ME and ECE curricula. The VCU School of engineering?s summer enrichment programs will be expanded to include this project related work in outreach activities with high school students.

渴望赠款的目的是通过计算模拟研究可行性并评估可植入设备设计的完整性，并为特定的流量和交付时间优化设计。该目标将通过执行以下任务来实现：（i）通过长度，身高和宽度的纳米通道阵列来开发设计概念并进行计算模拟，并模拟几种候选药物分子的药物释放动力学； （ii）优化特定流量和交付时间的设计。基于优化的设计，将探索原型模型。 This approach of using computations and design optimization for drug device design and integrity has never been examined for AMD devices due to challenges in size and extended delivery time.Intellectual meritThis project is a high-risk and high payoff and will provide a fundamental understanding of the physical and mechanical interactions through nano-channels of the drug delivery design and will provide valuable scientific insights into integration characteristics and implantable drug delivery devices.调查AMD的设计完整性和植入设备的整合，例如该急切项目中提出的植入设备，将有助于降低与频繁注射相关的成本和风险，并以受控的方式以及以对AMD疾病的要求进行促进药物，以治疗AMD疾病，以治疗AMD疾病。整个社会。该项目将为本科生和研究生提供与药物输送设备，计算研究和优化有关的多学科知识和培训。研究结果将被整合到ME和ECE课程中的PI教学课程中。 VCU工程学院的夏季丰富计划将进行扩展，以将与高中生的外展活动相关。