MEMS Device for Molecular Sorting and Pumping with Moving Boundaries

用于分子分选和移动边界泵浦的 MEMS 器件

• 批准号: 0725496
• 负责人: Ramana Pidaparti
• 金额: $ 30万
• 依托单位: Virginia Commonwealth University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0725496&HistoricalAwards=false
• 关键词: MEMS; Device; Molecular; Sorting; Pumping

MEMS Device for Molecular Sorting and Pumping with Moving BoundariesThe objective of this research is to design, fabricate, and optimize an active MEMS device for microfluidic pumping and molecular sorting. The approach is to use cascaded moving boundaries coupled with a specific geometric design of nozzle and diffuser elements to create a highly efficient unidirectional flow. For filtering, a surface acoustic wave generator will be integrated in the device to actively modulate the transport and surface adhesion of specific compounds. Microfabrication of the device will be performed using polydimethylsiloxane polymer, electrostatic actuation, and piezoelectric technology, based on computational simulations of the design. The prototype device will be used to validate the initial numerical design and the computational model will then be used to further optimize the device.Intellectual Merit: The proposed research will contribute to basic developments through coupled fluid-structure simulations and prototype fabrication in the design and synthesis of MEMS devices with moving boundaries for effective pumping and molecular sorting. The proposed device will significantly improve existing technology by creating unidirectional flow from a microfluidic moving boundary system. This research will extend the current state-of-the-art in the areas of computational simulations, MEMS device design and fabrication, and optimization.Broader Impacts: Development of a MEMS device aided by computational simulations will lead to the design of micro-/nanoscale systems for on-chip biological fluid diagnostic systems, targeted drug delivery, and immunoisolation of bio-artificial organs. Lab-on-a-chip systems that will benefit from this work will ultimately provide inexpensive and fast laboratory diagnostic and assessment tools to medical, environmental, and military personnel in clinical settings or in remote, rural, and poorly served locations. Graduate and undergraduate students involved in this research will acquire multidisciplinary training in the fields of computational modeling, micro-device fabrication, and biological applications.

该研究的MEMS设备用于分子分类和泵送的目标是设计，制造和优化用于微流体泵送和分子排序的活动MEMS设备。 该方法是使用级联的移动边界以及喷嘴和扩散器元素的特定几何设计来创建高效的单向流动。 为了过滤，将在设备中集成表面声波发生器，以主动调节特定化合物的传输和表面粘附。基于设计的计算模拟，将使用聚二甲基硅氧烷聚合物，静电驱动和压电技术进行微分解。 原型设备将用于验证初始数值设计，然后将使用计算模型来进一步优化设备。智能优点：拟议的研究将通过耦合的流体结构模拟和原型制造在MEMS设备的设计和合成中，从而有助于有效的泵送和分类。 提出的设备将通过从微流动移动边界系统创建单向流程来显着改善现有技术。 这项研究将扩大计算模拟，MEMS设备设计和制造以及优化影响的领域的最新最新技术。BRODER的影响：通过计算模拟协助的MEMS设备的开发将导致设计用于芯片生物学流体流体系统的微型/纳米级系统，以实现的药物诊断，靶向药物递送，靶向药物递送，Bio-bio-Mealtor of Bio-Mealter或Mntortal Organs。将从这项工作中受益的实验室芯片系统最终将在临床环境或偏远，农村和服务不善的地方为医疗，环境和军事人员提供廉价且快速的诊断和评估工具。 参与这项研究的研究生和本科生将在计算建模，微设备制造和生物应用领域中获得多学科培训。