Chemical Glycosylation: Reactions and Mechanism

化学糖基化：反应和机制

• 批准号: 1058112
• 负责人: Alexei Demchenko
• 金额: $ 40.43万
• 依托单位: University of Missouri-Saint Louis
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-15 至 2015-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1058112&HistoricalAwards=false
• 关键词: Chemical; Glycosylation; Reactions; Mechanism

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Alexei Demchenko of the Department of Chemistry and Biochemistry at the University of Missouri-St. Louis will develop effective approaches to stereocontrolled chemical glycosylation. This will be achieved by developing a reliable toolkit for studying the reaction pathways by which thioglycosides, glycosyl bromides, and the sulfonium salt intermediates form, isomerize and react. Successful completion of the proposed research lies in the project's contributions to basic and applied sciences developed at the interface of modern synthetic and mechanistic carbohydrate chemistries. The broader impacts (and the key for success) of this program is the participation of undergraduate and graduate students, who will receive solid training in the research methods and achieve all key milestones in this project. The University of Missouri-St. Louis and the Demchenko laboratory are well positioned and strongly committed to broaden participation of research students from underrepresented groups, advance discovery of new reactions while promoting teaching, training and learning, and benefit society by developing stereocontrolled reactions for the synthesis of glycosidic linkages by means of which the most common organic molecules and many therapeutic agents connect.

在这个由化学系化学合成项目资助的项目中，密苏里大学圣路易斯分校化学和生物化学系的Alexei Demchenko教授将开发有效的立体控制化学糖基化方法。这将通过开发一个可靠的工具包来实现，该工具包用于研究硫代糖苷、糖基溴和锍盐中间体形成、异构化和反应的反应途径。成功完成拟议的研究在于该项目对现代合成和机械碳水化合物化学界面上开发的基础和应用科学的贡献。该计划的更广泛的影响（和成功的关键）是本科生和研究生的参与，他们将接受研究方法的扎实培训，并实现该项目的所有关键里程碑。密苏里大学圣路易斯分校和Demchenko实验室处于有利地位，并坚定地致力于扩大来自代表性不足群体的研究生的参与，在促进教学，培训和学习的同时推进新反应的发现，并通过开发用于糖苷键合成的立体控制反应来造福社会，其中最常见的有机分子和许多治疗剂连接。