SBIR Phase II: 4-Dimensional Optical Tissue Imaging by Variable Digital Illumination

SBIR 第二阶段：通过可变数字照明进行 4 维光学组织成像

• 批准号: 1058146
• 负责人: Jeffrey Thatcher
• 金额: $ 50万
• 依托单位: Spectral MD Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-15 至 2015-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1058146&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Dimensional; Optical

This Small Business Innovation Research (SBIR) Phase II project has as its main objective the development of a mobile physiological optical imaging hardware and software system to empower clinicians with the ability to deploy, capture, assess and distribute standards compliant image data characterizing deep wounds and cardiovascular conditions. The mobile system will allow clinicians to rapidly identify the presence of hidden wound conditions or problematic blood flow patterns thus allowing care facilities to provide more cost effective and informed care to their patients, while minimizing financial losses associated with wound related hospital acquired conditions. The intellectual merit of this project lies in its scientific pursuit to define, develop, and distribute a comprehensive systems platform that will significantly accelerate the deployment of suitable physiological optical imaging solutions into the market. The research includes linking illumination patterns to physiological conditions while implementing mapping transfer functions by way of digital signal processing. The research objectives include system definition, integration, algorithmic optimization, and clinical validations. The broader impact/commercial potential of this project is to provide substantially affordable noninvasive imaging tools that may be used to assist in treatments that are more accessible to persons in remote areas or those having economic disadvantages. The portable device increases the ability of qualified clinicians to access patient wound care imaging diagnostics remotely, improving quality of care and accessibility to society. Broader commercial benefits include reductions in hospital visits and stays due to more thorough wound assessments and greater accessibility. The mobile system will enable care decisions that are more closely coupled with the state of the underlying tissue and related hemodynamics. It will also allow clinicians and patients to more effectively monitor the benefits of care decisions. The development of the novel and cost-effective optical system to facilitate the imaging of clinically and physiologically meaningful information will fill a void in the medical imaging industry for a point of care solution capable of providing quantitative visualization of physiological processes critical to wound care. The development of the mobile imaging technology will enhance scientific and technological understanding in the areas of optical-tissue image mapping, optoelectronic illumination systems, image processing, clinical applicability and real-time imaging scenarios.

这项小型企业创新研究（SBIR）二期项目的主要目标是开发一种移动生理光学成像硬件和软件系统，使临床医生能够部署、捕获、评估和分发符合标准的图像数据，以表征深度伤口和心血管疾病。移动系统将使临床医生能够快速识别隐藏的伤口状况或有问题的血流模式，从而使护理机构能够为患者提供更具成本效益和知情的护理，同时最大限度地减少与伤口相关的医院获得性疾病相关的经济损失。该项目的智力价值在于其科学的追求，定义，开发和分发一个全面的系统平台，这将大大加快合适的生理光学成像解决方案进入市场的部署。该研究包括将照明模式与生理条件联系起来，同时通过数字信号处理实现映射传递函数。研究目标包括系统定义、集成、算法优化和临床验证。该项目的更广泛的影响/商业潜力是提供基本上负担得起的非侵入性成像工具，这些工具可用于帮助偏远地区或经济弱势群体更容易获得的治疗。便携式设备增加了合格的临床医生远程访问患者伤口护理成像诊断的能力，提高了护理质量和社会可及性。更广泛的商业利益包括，由于更彻底的伤口评估和更大的可及性，减少了住院次数和住院时间。移动系统将使护理决策更紧密地与底层组织和相关血流动力学的状态相结合。它还将使临床医生和患者能够更有效地监测护理决策的益处。这种新型的、具有成本效益的光学系统的发展，有助于临床和生理上有意义的信息的成像，将填补医学成像行业的空白，因为它能够提供对伤口护理至关重要的生理过程的定量可视化。移动成像技术的发展将增强对光学组织图像映射、光电照明系统、图像处理、临床适用性和实时成像场景等领域的科学和技术理解。