Fundamental Investigations of Electrospray Mass Spectrometry

电喷雾质谱的基础研究

• 批准号: 1058764
• 负责人: Richard Cole
• 金额: $ 37.5万
• 依托单位: University of New Orleans
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1058764&HistoricalAwards=false
• 关键词: Fundamental; Investigations; Electrospray; Mass; Spectrometry

With support from the Chemical Measurement and Imaging Program in the Division of Chemistry, Prof. Richard Cole and his group at the University of New Orleans seek to investigate ways to improve electrospray (ES) mass spectrometry by building upon previous innovations in the development of anion attachment electrospray mass spectrometry; by detailed mapping of current and potential distributions within the ES emitter; and by optimization of detection of weakly-associated complexes in biological solutions. Efforts include development of "regioselective" anion attachment for selective detection of specific binding sites. This research will provide a means to improve the ability to detect and identify compounds such as steroids. A related aim is to improve the understanding of binding like that between tannins in food and proteins in saliva; this may provide a new means to gauge the loss in antioxidant capacity of potential tannin food additives. Derivation of a mathematical model to describe electrical current and potential within the electrospray device will advance the fundamental understanding of electrochemical processes in electrospray.The project expands an existing partnership between the University of New Orleans and Xavier University of Louisiana. This endeavor will thus enlarge and enrich opportunities for graduate students and undergraduates (including members of underrepresented groups) at both institutions, specifically by widening exposure to mass spectrometry.

在化学系化学测量和成像项目的支持下，新奥尔良大学的Richard科尔教授和他的小组试图通过以下方法来研究改进电喷雾质谱的方法：建立在阴离子附着电喷雾质谱开发的先前创新基础上;详细绘制电喷雾发射器内的电流和电势分布;以及通过优化生物溶液中弱缔合复合物的检测。 努力包括开发用于选择性检测特异性结合位点的“区域选择性”阴离子附着。这项研究将提供一种手段，以提高检测和识别化合物，如类固醇的能力。一个相关的目的是提高对食物中单宁和唾液中蛋白质之间结合的理解;这可能提供一种新的方法来衡量潜在单宁食品添加剂抗氧化能力的损失。推导出一个数学模型来描述电喷雾装置内的电流和电势，将促进对电喷雾电化学过程的基本理解。该项目扩大了新奥尔良大学和路易斯安那州泽维尔大学之间现有的合作关系。因此，这一奋进将扩大和丰富两个机构的研究生和本科生（包括代表性不足的群体的成员）的机会，特别是通过扩大接触质谱。