Conjugated Polymer Nanoparticles for Nanoscale Chemical Microscopy

克莱姆森大学的Jason麦克尼尔教授得到化学系化学测量和成像（CMI）项目的支持，开发用于传感和高分辨率荧光成像和跟踪应用的共轭聚合物纳米颗粒（CPN）。本研究的具体目标是：（1）使用掺杂剂来提高CPNs的稳定性和亮度，（2）表征CPNs中激子和载流子的纳米尺度电子物理，优化CPNs的光开关和传感特性，（3）研究CPNs的光开关和传感特性。以及（3）利用高分辨率成像技术观察CPN的运动和CPN内的极化子动力学。最终目标是建立新的成像和传感技术，在纳米材料、荧光和生物分子动力学方面的创新能力。如果成功，拟议的研究将导致纳米分辨率成像的重要进展，从而对纳米技术，化学，生物学和健康科学产生积极影响。该项目的学生和其他参与者将获得纳米科学、先进成像和传感技术方面的宝贵培训。

Professor Jason McNeill of Clemson University is supported by the Chemical Measurement and Imaging (CMI) program in the Division of Chemistry to develop conjugated polymer nanoparticles (CPNs) for sensing and high resolution fluorescent imaging and tracking applications. The specific aims of the proposed research are: (1) to use dopants to increase the stability and brightness of CPNs; (2) to characterize the nanoscale photophysics of excitons and charge carriers in CPNs and optimize the photoswitching and sensing properties of CPNs; and (3) to use high resolution imaging to observe CPN motion and polaron dynamics within CPNs.The ultimate objective is to create new imaging and sensing capabilities with innovation in nanomaterials, fluorescence and biomolecular dynamics. If successful, the proposed research will result in important advances in imaging with nanometer resolution, thus positively impacting nanotechnology, chemistry, biology and the health sciences. Students and other participants in the project will be provided with valuable training in nanoscience, advanced imaging and sensing technologies.