Chemical sensing of thiol compounds with gold nanoparticles conjugated with thermoresponsive polymer

将金纳米粒子与热响应性聚合物结合制备了热响应性金纳米复合材料，并对其检测巯基化合物的比色功能进行了研究。热响应金纳米复合材料表现出热刺激、加热和冷却的分解。巯基单肽半胱氨酸和同型半胱氨酸抑制其降解，巯基二肽半胱氨酸和巯基三肽谷胱甘肽促进其降解。研究了半胱氨酸、谷胱甘肽和γ- gpt的比色定量方法。

Thermoresponsive gold nanocomposites have been fabricated by conjunction of gold nanoparticles with thermoresponsive polymers and their colorimetric functions to sense sulfhydryl compounds have been also examined. The thermoresponsive gold nanocomposites exhibit disassembly by thermal stimuli, heating followed by cooling. Cysteine and homocysteine, sulfhydryl monopeptide, inhibit the disassembly while cysteinylglycine, sulfhydryl dipeptide, and glutathione, sulfhydryl tripeptides, promote the disassembly. Colorimetric quantification methods of cysteine, glutathione andγ-GPT are exploited based on the inhibition and promotion of the disassembly.