Understanding Elastomer/Stiff Material Interfaces in Fluidic Environments for Bioanalytical Microdevices

了解生物分析微型设备流体环境中的弹性体/刚性材料界面

基本信息

  • 批准号:
    1063714
  • 负责人:
  • 金额:
    $ 13.5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-06-01 至 2014-06-30
  • 项目状态:
    已结题

项目摘要

This project is a combined experimental and theoretical study of the stability of interfaces between elastomers and stiff materials (such as glass and metals). The central objective is to identify critical parameters (such as adhesion energy, pressures and dimensions) that control thin film debonding in the presence of different fluidic environments. The results will then be used to identify geometries and surface treatments that improve reliability and performance in fluidic bioanalytical microdevices. The approach is to create micropatterned channels that are capped by elastomer films: interface stability will then be quantified (using optical and interferometric measurements) as different fluids are injected into the channels. This study will include the characterization of interfaces in existing devices that perform DNA extraction, amplification and detection.The insights generated by this program will provide societal benefits by enabling the development microdevices that perform biochemical manipulations for genomic and proteomic analysis. The ability to control interface stability will not only improve device reliability, but also enable simplified fluidic flow control using passive features that open and close based on tailored interface behavior (as opposed to direct mechanical actuation). This development will facilitate both scientific discovery (by broadening the range of fluidic manipulations at the microscale) and the targeted development of portable devices for clinical applications. The project also bears direct relevance for flexible "macroelectronics", e.g. video displays that are created by depositing electronic features on flexible elastomer substrates. The project will integrate research and education by placing research devices in undergraduate laboratories focusing on design, rapid prototyping, material properties, dynamics and chemical separations.
该项目是对弹性体和刚性材料(例如玻璃和金属)之间界面稳定性的实验和理论相结合的研究。中心目标是确定在不同流体环境下控制薄膜脱粘的关键参数(例如粘附能、压力和尺寸)。 然后,结果将用于确定可提高流体生物分析微型设备的可靠性和性能的几何形状和表面处理。 该方法是创建由弹性体薄膜覆盖的微图案通道:当不同的流体注入通道时,界面稳定性将被量化(使用光学和干涉测量)。这项研究将包括执行 DNA 提取、扩增和检测的现有设备中接口的表征。该项目产生的见解将通过开发能够执行基因组和蛋白质组分析生化操作的微型设备来提供社会效益。控制界面稳定性的能力不仅可以提高设备的可靠性,而且还可以使用基于定制界面行为(而不是直接机械驱动)打开和关闭的被动功能来简化流体流量控制。 这一发展将促进科学发现(通过扩大微尺度流体操作的范围)和临床应用便携式设备的有针对性的开发。该项目还与灵活的“宏观电子学”直接相关,例如通过在柔性弹性体基板上沉积电子特征而创建的视频显示器。该项目将通过在本科生实验室放置研究设备来整合研究和教育,重点关注设计、快速原型制作、材料特性、动力学和化学分离。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Matthew Begley其他文献

Minimizing finite viscosity enhances relative kinetic energy absorption in bistable mechanical metamaterials but only with sufficiently fine discretization: A nonlinear dynamical size effect
在双稳态机械超材料中,最小化有限粘度可增强相对动能吸收,但仅在足够精细的离散化情况下:一种非线性动力学尺寸效应
  • DOI:
    10.1016/j.jmps.2025.106105
  • 发表时间:
    2025-07-01
  • 期刊:
  • 影响因子:
    6.000
  • 作者:
    Haning Xiu;Ryan Fancher;Ian Frankel;Patrick Ziemke;Müge Fermen-Coker;Matthew Begley;Nicholas Boechler
  • 通讯作者:
    Nicholas Boechler

Matthew Begley的其他文献

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{{ truncateString('Matthew Begley', 18)}}的其他基金

Understanding Elastomer/Stiff Material Interfaces in Fluidic Environments for Bioanalytical Microdevices
了解生物分析微型设备流体环境中的弹性体/刚性材料界面
  • 批准号:
    0800790
  • 财政年份:
    2008
  • 资助金额:
    $ 13.5万
  • 项目类别:
    Standard Grant
SST: A New Class of Polymeric Micro-Devices for Chemical Sensing with Integrated Microelectronic/Optical Transduction
SST:一种具有集成微电子/光转换功能的新型聚合物微器件,用于化学传感
  • 批准号:
    0529076
  • 财政年份:
    2005
  • 资助金额:
    $ 13.5万
  • 项目类别:
    Standard Grant
CAREER: Determining Time and Temperature-Dependent Material Properties for Small Components: Integrated Education and Research
职业:确定小部件随时间和温度变化的材料特性:综合教育和研究
  • 批准号:
    0196438
  • 财政年份:
    2001
  • 资助金额:
    $ 13.5万
  • 项目类别:
    Standard Grant
CAREER: Determining Time and Temperature-Dependent Material Properties for Small Components: Integrated Education and Research
职业:确定小部件随时间和温度变化的材料特性:综合教育和研究
  • 批准号:
    9984517
  • 财政年份:
    2000
  • 资助金额:
    $ 13.5万
  • 项目类别:
    Standard Grant
Acquisition of a Nano-Indenter for Moderately Elevated Temperatures
获得适用于中等高温的纳米压头
  • 批准号:
    9802716
  • 财政年份:
    1998
  • 资助金额:
    $ 13.5万
  • 项目类别:
    Standard Grant

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