SST: A New Class of Polymeric Micro-Devices for Chemical Sensing with Integrated Microelectronic/Optical Transduction

SST：一种具有集成微电子/光转换功能的新型聚合物微器件，用于化学传感

• 批准号: 0529076
• 负责人: Matthew Begley
• 金额: $ 40万
• 依托单位: University of Virginia Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0529076&HistoricalAwards=false
• 关键词: SST; New; Class; Polymeric; Micro

Abstract0529076Mattew BegleyUniv VirginiaThis research project will develop polymeric chemical sensors that strongly couple selective surface adsorption to mechanical deformation. The ultimate goal is to make devices that amplify the effects of surface adsorption via mechanical instabilities (i.e.,buckling) to facilitate optical and electronic transduction approaches that can be integrated with lab-on-a-chip technology. A specific focus is the implementation of polymers as structural elements in microdevices to exploit their inherent flexibility and biocompatibility. The project has three parallel focus areas: (i) surface functionalization of polymers - surface treatments will be identified which make PDMS chemically-selective for specific target molecules, (ii) microfabrication of freestanding polymeric structures - developing processing techniques to create ultra-compliant structures which experience large deformation upon adsorption, and (iii) optical transduction - creating microchip devices with integrated transduction features. The research is expected to make fundamental advances regarding effective pathways to selective binding with polymeric surfaces, and connections between microfabrication processes and thermomechanical properties (such as modulus and residual stress). The proposed program will directly quantify microdevice performance in terms of surface adsorption, microscale deformation, and thermomechanical properties, using a combination of atomic force microscopy, optical interferometry and nanomechanical testing.

该研究项目将开发选择性表面吸附与机械变形强耦合的聚合物化学传感器。最终目标是制造一种通过机械不稳定性（即屈曲）放大表面吸附效应的设备，以促进可与芯片实验室技术集成的光学和电子转导方法。一个特定的焦点是实现聚合物作为微器件的结构元素，以利用其固有的灵活性和生物相容性。该项目有三个平行的重点领域：(i)聚合物的表面功能化-将确定使PDMS对特定目标分子具有化学选择性的表面处理，（ii）独立聚合物结构的微制造-开发加工技术，以创建吸附时经历大变形的超柔顺结构，以及（iii）光学转导-创建具有集成转导功能的微芯片设备。该研究有望在与聚合物表面选择性结合的有效途径以及微加工工艺与热机械性能（如模量和残余应力）之间的联系方面取得根本性进展。该计划将使用原子力显微镜、光学干涉测量和纳米力学测试相结合，直接量化微器件在表面吸附、微尺度变形和热机械性能方面的性能。