Dissertation Research: The Developmental basis of Convergent Evolution

论文研究：趋同进化的发展基础

• 批准号: 1110246
• 负责人: Artyom Kopp
• 金额: $ 1.26万
• 依托单位: University of California-Davis
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1110246&HistoricalAwards=false
• 关键词: Dissertation; Research; Developmental; basis; Convergent

This research investigates the genetic basis of pigmentation differences in fruit flies of the genus Drosophila. It is a part of an effort to develop Drosophila pigmentation as an evolutionary metamodel. Established metamodels are necessary for the elucidation of any general rules in evolution. They test whether certain traits and gene networks evolve in a reproducible fashion. Previously the regions involved in color pattern evolution in one species pair were identified, and the genes are in the process of being characterized. This grant will improve this dissertation through funding an analysis of the chromosomal regions involved in pigmentation differences in an additional species pair. This comparative component will be integral to the formation of an unbiased understanding of the dynamics of convergent evolution in this system.Metamodels are being actively developed in several systems, such as sticklebacks and mice. None of these endeavors account for the effect of network structure in shaping the dynamics of parallel evolution. Within Drosophila this is possible as most, though not all, genes in the pathway have been characterized. Furthermore--in addition to its scientific merit--this research generates opportunities for training in research and includes individuals from underrepresented groups. Undergraduates from this lab have continued on to graduate school and participated in local and national research symposia. This research is also being used to develop to develop lesson plans that promote engaged learning and improve biology education.

这项研究调查了果蝇属果蝇色素沉着差异的遗传基础。 这是将果蝇色素沉着开发为进化元模型的努力的一部分。 已建立的元模型对于阐明进化中的任何一般规则是必要的。 他们测试某些特征和基因网络是否以可复制的方式进化。 此前，一对物种中涉及颜色模式进化的区域已被识别，并且基因正在被表征。这笔赠款将通过资助对另一对物种中涉及色素沉着差异的染色体区域的分析来改进本论文。 这种比较成分对于形成对该系统中趋同进化动力学的公正理解是不可或缺的。元模型正在多个系统中积极开发，例如刺鱼和小鼠。这些努力都没有解释网络结构在塑造并行进化动态方面的影响。在果蝇中，这是可能的，因为该途径中的大多数（尽管不是全部）基因已被表征。此外，除了其科学价值外，这项研究还为研究培训提供了机会，并包括来自代表性不足群体的个人。 该实验室的本科生继续升读研究生并参加地方和国家研究研讨会。 这项研究还被用来制定课程计划，以促进参与式学习和改善生物教育。