DISSERTATION RESEARCH: Genome-wide SNP genotyping to identify candidate loci responsible for divergence in temperature performance within a population of thermophilic cyanobacteria
论文研究:全基因组 SNP 基因分型,以确定导致嗜热蓝藻种群内温度表现差异的候选位点
基本信息
- 批准号:1110819
- 负责人:
- 金额:$ 0.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-06-01 至 2012-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
A central goal of evolutionary biology is understanding how ecological diversity arises and is maintained in natural populations. White Creek, in Yellowstone National Park, is home to a population of the cyanobacterium, Mastigocladus laminosus, which grows along a thermal gradient of 37 to 55ºC. While genetically identical for much of the genome, the population has members that have specialized and adapted to live at different temperature zones along creek. This study takes an innovative approach using genomic data to identify strong candidates for genes responsible for natural variation within the population and that are temperature associated. Genes thus identified can shed light on the type, function, and number of genes involved in thermal adaptation. Fundamental questions regarding how ecological niches develop in populations are: 1) what kind of genes are involved, regulatory or protein encoding? 2) What do the genes encode? and 3) How many genes are involved? This study's unique focus on a natural population facing a well defined environmental gradient, allows a robust analysis of associations between genetic makeup and the environmental variable. Undergraduate researchers in the University of Montana's Introductory Multicultural Summer Undergraduate Research Experience and the HHMI supported Montana Integrative Learning Experience for Students have had and will continue to have opportunities to work in the lab on this study. An educational module on microbiology and evolution will be developed from this study for use by Ecology Project International, which draws high school students from all over the U.S. and Latin America to Yellowstone NP.
进化生物学的一个核心目标是理解生态多样性是如何在自然种群中产生和维持的。黄石国家公园的白色溪是蓝细菌--层状鞭枝藻(Mastigocladus laminosus)种群的家园,这种细菌沿着37至55ºC的温度梯度生长。虽然大部分基因组在遗传上是相同的,但种群中有一些成员已经专门化并适应了沿着小溪不同的温度区。这项研究采用了一种创新的方法,使用基因组数据来识别负责人口内自然变异的基因的强有力的候选者,并且与温度相关。由此确定的基因可以阐明参与热适应的基因的类型、功能和数量。关于生态位如何在种群中发展的基本问题是:1)涉及什么样的基因,调节或蛋白质编码?2)基因编码什么?(3)有多少基因参与其中?这项研究的独特重点是自然人口面临一个明确的环境梯度,允许一个强大的分析之间的关联遗传组成和环境变量。蒙大拿大学的介绍性多元文化夏季本科生研究经验和HHMI支持的蒙大拿州学生综合学习经验的本科生研究人员已经并将继续有机会在实验室进行这项研究。这项研究将开发一个关于微生物学和进化的教育模块,供国际生态项目使用,该项目吸引了来自美国和拉丁美洲各地的高中生到黄石国家公园学习。
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Scott Miller其他文献
CADET: Computer Assisted Discovery Extraction and Translation
CADET:计算机辅助发现提取和翻译
- DOI:
- 发表时间:
2017 - 期刊:
- 影响因子:0
- 作者:
Benjamin Van Durme;Thomas Lippincott;Kevin Duh;Deana Burchfield;Adam Poliak;Cash Costello;Timothy W. Finin;Scott Miller;J. Mayfield;Philipp Koehn;Craig Harman;Dawn J Lawrie;Chandler May;Max Thomas;Annabelle Carrell;Julianne Chaloux;Tongfei Chen;Alex Comerford;Mark Dredze;Benjamin Glass;Shudong Hao;Patrick Martin;Pushpendre Rastogi;Rashmi Sankepally;Travis Wolfe;Ying;Ted Zhang - 通讯作者:
Ted Zhang
Camera Network for Use in Weather Operations, Research and Education
用于天气操作、研究和教育的摄像机网络
- DOI:
- 发表时间:
2022 - 期刊:
- 影响因子:0
- 作者:
J. Brotzge;Junhong (June) Wang;N. Bain;Scott Miller;Crystal Perno - 通讯作者:
Crystal Perno
The Negative Screening Rate of Second Cervical Medial Branch Blocks in Patients With Positive First Blocks: A Retrospective Chart Review
- DOI:
10.1016/j.inpm.2023.100325 - 发表时间:
2023-01-01 - 期刊:
- 影响因子:
- 作者:
Taylor R. Burnham;Timothy M. Curtis;Scott Miller;Marc Caragea;Omar Rachdi;Jason E. Mascoe;Keith T. Kuo;Emily Y. Huang;Cailtlin D. Faust;Tyler Clark;Austin Le;Masaru Teramoto;Zachary L. McCormick;Aaron M. Conger - 通讯作者:
Aaron M. Conger
TRAUMA INDUCED BRUGADA PATTERN
- DOI:
10.1016/s0735-1097(19)33530-2 - 发表时间:
2019-03-12 - 期刊:
- 影响因子:
- 作者:
Faraz Nasim Kazmi;Amina Adil;Scott Miller;Raymond Kawasaki - 通讯作者:
Raymond Kawasaki
THE HEART AND SOUL OF CHANGE: DELIVERING WHAT WORKS IN THERAPY
变革的核心和灵魂:提供有效的治疗方法
- DOI:
- 发表时间:
2013 - 期刊:
- 影响因子:0
- 作者:
B. Duncan;Scott Miller;E. Bruce;Wampold - 通讯作者:
Wampold
Scott Miller的其他文献
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{{ truncateString('Scott Miller', 18)}}的其他基金
Collaborative Research: Autonomous eddy covariance air-sea CO2 flux system for moored buoys
合作研究:系泊浮标的自主涡协方差海海二氧化碳通量系统
- 批准号:
2319150 - 财政年份:2023
- 资助金额:
$ 0.96万 - 项目类别:
Standard Grant
Collaborative Research: PurSUiT: Phylogenomics and taxonomic revision of Rhopalodiales - diatoms with obligate cyanobacterial endosymbionts
合作研究:PurSUiT:Rhopalodiales - 具有专性蓝细菌内共生体的硅藻的系统基因组学和分类学修订
- 批准号:
2222945 - 财政年份:2022
- 资助金额:
$ 0.96万 - 项目类别:
Standard Grant
Applying bacterial growth theory to understand the evolution of thermal performance
应用细菌生长理论来了解热性能的演变
- 批准号:
1755407 - 财政年份:2018
- 资助金额:
$ 0.96万 - 项目类别:
Standard Grant
GOALI: Characterization of Material Transfer in Friction Stir Processing With a Consumable Tool
GOALI:使用消耗工具表征摩擦搅拌加工中的材料转移
- 批准号:
1763147 - 财政年份:2018
- 资助金额:
$ 0.96万 - 项目类别:
Standard Grant
EAGER: Robust, Low-power Strategies for Unattended Micrometeorological Buoy Deployments in Extreme Cold and Freezing Spray
EAGER:用于极冷和冰冻喷雾中无人值守微气象浮标部署的稳健、低功耗策略
- 批准号:
1841621 - 财政年份:2018
- 资助金额:
$ 0.96万 - 项目类别:
Standard Grant
Collaborative Research: A new system for air-sea CO2 flux measurements from moored and unmanned surface platforms
合作研究:用于从系泊和无人水面平台测量海气二氧化碳通量的新系统
- 批准号:
1737238 - 财政年份:2017
- 资助金额:
$ 0.96万 - 项目类别:
Standard Grant
Structural variation of the nitrogen-fixing heterocyst: Addressing the role of gas permeability in evolutionary divergence
固氮异形体的结构变异:解决气体渗透性在进化分歧中的作用
- 批准号:
1147195 - 财政年份:2012
- 资助金额:
$ 0.96万 - 项目类别:
Standard Grant
GOALI: Friction Stir Forming Process for Joining Dissimilar Metals
GOALI:用于连接异种金属的搅拌摩擦成形工艺
- 批准号:
1131845 - 财政年份:2011
- 资助金额:
$ 0.96万 - 项目类别:
Standard Grant
Air-Sea Fluxes of Momentum, Heat, and Carbon Dioxide at High Wind Speeds in the Southern Ocean
南大洋高风速下的动量、热量和二氧化碳的海气通量
- 批准号:
1043623 - 财政年份:2011
- 资助金额:
$ 0.96万 - 项目类别:
Standard Grant
Workshop on Synthetic Chemistry 2011
2011年合成化学研讨会
- 批准号:
1137094 - 财政年份:2011
- 资助金额:
$ 0.96万 - 项目类别:
Standard Grant
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