Synthesis and Functionalisation of nanomaterials by short pulse laser and its applications

我的研究小组在直接从固体目标合成短脉冲激光纳米材料（不使用化学试剂）及其各种应用的功能化方面取得了重要发现。我们已经发现合成的纳米材料具有多相SERS超灵敏检测：本研究项目将研究非等离子体SERS，并将知识应用于开发原位监测细胞活动的技术，感知有毒化学物质，并从距离检测爆炸物的痕迹。3)多功能治疗剂：这些工程生物纳米材料具有多种功能，如SERS增强、荧光增强和生物相容性。对这些生物纳米材料的研究可能会导致新的癌症治疗方法，将几种功能整合到一种药物中，从而实现多模式诊断，并阻止癌细胞的生长，同时对健康细胞没有副作用。我们在这一领域的研究将为提高肿瘤纳米药物的特异性、选择性和安全性做出重要贡献。4)纺织品快速愈合创面敷料及抗菌涂层：工程三维纳米结构的生物活性和生物相容性将用于再生医学和临床组织工程中新型生物功能化支架和可植入材料的开发，所获得的知识将用于开发士兵创面敷料和自洁布。总之，拟议的研究本质上是多学科的，将在下一代纳米材料的合成和功能化方面产生高质量的HQP培训，用于化学/生物传感、防御、癌症治疗、伤口愈合和诊断应用的各种应用。

My research group has made important findings in short-pulsed laser nano material synthesis directly from solid targets (without the employment of chemical agents) and its functionalisation for various applications. We have discovered that synthesized nano-materials possess multiple phases 2) SERS-based ultrasensitive detection: This research program will investigate non-plasmonic SERS & apply the knowledge to develop techniques for in-situ monitoring of cell activity, sensing toxic chemicals, and detecting traces of explosives from standoff distances. 3)All-in-one therapeutic agents: Many of these engineered Bio Nano-Materials are multi-functionalized, such as with SERS enhancement, fluorescent enhancement and biocompatibility. Research of these bio-nanomaterials may lead to new cancer therapeutics that integrates several functions into a single medication that would enable mutli-mode diagnoses and impede the growth of cancer cells with no side effects on healthy cells. Our research in this area will contribute significantly to the improvement of the specificity, selectivity and safety of cancer nanomedicine. 4)Rapid healing wound dressing and antibacterial coating for textiles: The bioactivity and biocompatibility of the engineered 3-D nanostructures will be used for developing new bio-functionalized scaffolds and implantable materials in regenerative medicine and clinical tissue engineering, and the knowledge gained will be used to develop wound dressing and self-cleaning cloth for soldiers. In summary, the proposed research is multidisciplinary in nature and will result in high quality HQP training in the synthesis and functionalisation of next-generation nano-materials for diverse applications in chemical/bio sensing, defence, cancer therapy, wound healing and diagnostic applications.