Organometallic Chemistry of High Oxidation State Palladium

化学部的这一奖项支持密歇根大学Melanie Sanford教授研究涉及Pd（III）和Pd（IV）中间体的化学计量反应的机制、范围、选择性和配体效应。所发现的反应性和选择性特征将有助于合理设计新的催化转化。钯是一种非常重要的过渡金属，广泛应用于碳-碳和碳杂原子键的均相催化转化。这些反应在药物、天然产物、精细化学品和商品化学品的合成中得到了广泛的应用。所提出的研究将证明在适当设计的高氧化态钯配合物上进行多种有机金属反应（包括碳氢活化、迁移插入和核化）的可行性。最终，本文建立的新的反应性和选择性谱将使新的催化转化的合理设计成为可能。PI和同事们将在密歇根州的另一个地点扩大一个名为“科学星期六”的高中生推广计划，该计划通过让学生们接触真实的类似研究的体验，促进更广泛地参与物理科学。该实验室培养了各种各样的学生（自2003年以来共有29名博士生和博士后），其中17名是女性，3名是代表性不足的少数群体成员。参与该项目的研究生和本科生将接受无机合成、无机反应机理和合成有机化学的跨学科培训。

This award in the Division of Chemistry supports research by Professor Melanie Sanford at the University of Michigan to investigate the mechanism, scope, selectivity, and ligand effects in stoichiometric reactions involving Pd(III) and Pd(IV) intermediates. The reactivity and selectivity profiles discovered will enable the rational design of new catalytic transformations. Palladium is an extremely important transition metal that is widely used in homogeneous catalytic transformations for the construction of carbon-carbon and carbon-heteroatom bonds. These reactions have found extensive application in the synthesis of pharmaceuticals, natural products, fine chemicals, and commodity chemicals. The proposed research will demonstrate the feasibility of diverse organometallic reactions (including C-H activation, migratory insertion, and nucleopalladation) at appropriately designed high oxidation state palladium complexes. Ultimately, the novel reactivity and selectivity profiles established herein will enable the rational design of new catalytic transformations.The PI and coworkers will expand an outreach program for high school students called "Science Saturdays", which promotes broader participation in the physical sciences by exposing students to an authentic research-like experience, to another site in Michigan. This laboratory trains a diverse set of students (29 total PhD students and post-docs since 2003), of whom 17 are women and 3 are members of underrepresented minority groups. Graduate and undergraduate students working on this project will receive interdisciplinary training in inorganic synthesis, inorganic reaction mechanisms, and synthetic organic chemistry.