Organometallic Chemistry of High Oxidation State Palladium

该奖项支持密歇根大学梅勒妮·桑福德教授的研究，该研究旨在研究Pd(III)和Pd(IV)中间体化学计量反应中的机理、范围、选择性和配体效应。所发现的反应性和选择性分布将使新催化转化的合理设计成为可能。钯是一种非常重要的过渡金属，广泛用于碳-碳和碳-杂原子键的均相催化转化。这些反应在医药、天然产物、精细化学品和商品化学品的合成中得到了广泛的应用。这项研究将证明各种有机金属反应(包括C-H活化、迁移插入和核配位)在适当设计的高氧化态钯配合物上的可行性。最终，这里建立的新颖的反应性和选择性曲线将使新的催化转化的合理设计成为可能。PI和同事们将扩展一个针对高中生的推广计划，名为“科学星期六”，该计划通过让学生接触真实的类似研究的体验来促进更广泛的物理参与，在密歇根州的另一个地点。这个实验室培养了各种各样的学生(自2003年以来共有29名博士生和博士后)，其中17名是女性，3名是代表不足的少数群体。从事这个项目的研究生和本科生将接受关于无机合成、无机反应机理和合成有机化学的跨学科培训。

This award in the Division of Chemistry supports research by Professor Melanie Sanford at the University of Michigan to investigate the mechanism, scope, selectivity, and ligand effects in stoichiometric reactions involving Pd(III) and Pd(IV) intermediates. The reactivity and selectivity profiles discovered will enable the rational design of new catalytic transformations. Palladium is an extremely important transition metal that is widely used in homogeneous catalytic transformations for the construction of carbon-carbon and carbon-heteroatom bonds. These reactions have found extensive application in the synthesis of pharmaceuticals, natural products, fine chemicals, and commodity chemicals. The proposed research will demonstrate the feasibility of diverse organometallic reactions (including C-H activation, migratory insertion, and nucleopalladation) at appropriately designed high oxidation state palladium complexes. Ultimately, the novel reactivity and selectivity profiles established herein will enable the rational design of new catalytic transformations.The PI and coworkers will expand an outreach program for high school students called "Science Saturdays", which promotes broader participation in the physical sciences by exposing students to an authentic research-like experience, to another site in Michigan. This laboratory trains a diverse set of students (29 total PhD students and post-docs since 2003), of whom 17 are women and 3 are members of underrepresented minority groups. Graduate and undergraduate students working on this project will receive interdisciplinary training in inorganic synthesis, inorganic reaction mechanisms, and synthetic organic chemistry.