Organometallic Chemistry of High Oxidation State Palladium

高氧化态钯的有机金属化学

• 批准号: 1111563
• 负责人: Melanie Sanford
• 金额: $ 35.4万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-15 至 2014-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1111563&HistoricalAwards=false
• 关键词: Organometallic; Chemistry; Oxidation; State; Palladium

This award in the Division of Chemistry supports research by Professor Melanie Sanford at the University of Michigan to investigate the mechanism, scope, selectivity, and ligand effects in stoichiometric reactions involving Pd(III) and Pd(IV) intermediates. The reactivity and selectivity profiles discovered will enable the rational design of new catalytic transformations. Palladium is an extremely important transition metal that is widely used in homogeneous catalytic transformations for the construction of carbon-carbon and carbon-heteroatom bonds. These reactions have found extensive application in the synthesis of pharmaceuticals, natural products, fine chemicals, and commodity chemicals. The proposed research will demonstrate the feasibility of diverse organometallic reactions (including C-H activation, migratory insertion, and nucleopalladation) at appropriately designed high oxidation state palladium complexes. Ultimately, the novel reactivity and selectivity profiles established herein will enable the rational design of new catalytic transformations.The PI and coworkers will expand an outreach program for high school students called "Science Saturdays", which promotes broader participation in the physical sciences by exposing students to an authentic research-like experience, to another site in Michigan. This laboratory trains a diverse set of students (29 total PhD students and post-docs since 2003), of whom 17 are women and 3 are members of underrepresented minority groups. Graduate and undergraduate students working on this project will receive interdisciplinary training in inorganic synthesis, inorganic reaction mechanisms, and synthetic organic chemistry.

化学部的这一奖项支持密歇根大学Melanie Sanford教授的研究，以研究涉及Pd（III）和Pd（IV）中间体的化学计量反应中的机制，范围，选择性和配体效应。所发现的反应性和选择性特征将使新的催化转化的合理设计成为可能。 钯是一种非常重要的过渡金属，广泛用于均相催化转化，用于构建碳-碳和碳-杂原子键。这些反应在药物、天然产物、精细化学品和日用化学品的合成中有着广泛的应用。拟议的研究将证明在适当设计的高氧化态钯配合物的各种有机金属反应（包括C-H活化，迁移插入和核钯化）的可行性。最终，本文建立的新型反应性和选择性特征将使新的催化转化的合理设计成为可能。PI和同事将扩大一个名为“科学星期六”的高中生外展计划，该计划通过让学生接触真实的研究体验来促进更广泛的物理科学参与，密歇根州的另一个地点。该实验室培养了一批多样化的学生（自2003年以来，共有29名博士生和博士后），其中17名是妇女，3名是代表性不足的少数群体成员。从事该项目的研究生和本科生将接受无机合成，无机反应机理和合成有机化学的跨学科培训。