Organometallic Chemistry of High Valent Nickel
高价镍的有机金属化学
基本信息
- 批准号:1664961
- 负责人:
- 金额:$ 45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-08-01 至 2021-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Organometallic Chemistry of High Valent NickelTransition metal catalysts are used to manufacture many important products, including life-saving pharmaceuticals, crop-protecting agrochemicals, and electronic materials. The cost and sustainability of these products are directly impacted by the development of new catalysts that are less expensive, that generate less waste, and that operate under milder conditions. A particularly important goal for the field is to replace catalysts that are based on rare and expensive precious metals (e.g. palladium) and towards those derived from inexpensive and more readily available metals (e.g., nickel). Often, however, the more desirable inexpensive metals have very different (and often problematic) properties, that make them difficult to use for these important applications. In this project Dr. Sanford and her research group are conducting detailed studies of nickel catalysts. The overall goal of this work is to determine how to control the properties of nickel catalysts to enable them to perform as well or better than their palladium analogues. Dr. Sanford is also actively involved in outreach activities that seek to increase the participation of women in science and engineering. For example, she is working with programs that engage middle-school aged girls in scientific activities and that train diverse graduate students for careers in science/technology.With funding from the Chemical Catalysis Program of the Chemistry Division, Dr. Sanford of the University of Michigan is studying the fundamental organometallic chemistry of high valent nickel intermediates [i.e., nickel(III) and nickel(IV) complexes]. Despite their potential relevance to a wide variety of important Ni-catalyzed cross-coupling and C-H functionalization reactions, the synthesis and reactivity of organometallic nickel(III) and nickel(IV) compounds has not been systematically explored. The current work is focused on establishing the feasibility and mechanisms of a variety of transformations at nickel(III) and nickel(IV) centers using both model systems and catalytic intermediates. The reactivity and selectivity profiles that are being established herein are expected to have a transformative impact on the design and optimization of new high valent Ni-catalyzed transformations. Dr. Sanford is also actively engaged in outreach programs aimed at broadening participation of women in science at the K-12, undergraduate, graduate, and faculty levels. Furthermore, her project is training a diverse group of scientists in the interdisciplinary areas of inorganic and organic synthesis, inorganic reaction mechanisms, electrochemistry, and catalysis. A well-trained and diverse scientific workforce is essential for continued advances in innovation and technology in the 21st century.
高价镍的有机金属化学过渡金属催化剂被用于制造许多重要的产品,包括救命药物、保护作物的农用化学品和电子材料。这些产品的成本和可持续性直接受到新催化剂开发的影响,这些催化剂更便宜,产生的废物更少,并且在更温和的条件下运行。该领域的一个特别重要的目标是取代以稀有和昂贵的贵金属(例如钯)为基础的催化剂,并转向以廉价和更容易获得的金属(例如镍)为基础的催化剂。然而,通常情况下,更理想的廉价金属具有非常不同的(而且往往是有问题的)性质,这使得它们很难用于这些重要的应用。在这个项目中,桑福德博士和她的研究小组正在对镍催化剂进行详细的研究。这项工作的总体目标是确定如何控制镍催化剂的性能,使其性能与其钯类似物一样或更好。桑福德博士还积极参与旨在增加妇女在科学和工程领域的参与的外联活动。例如,她正在参与的项目是让中学年龄的女孩参与科学活动,并为科学/技术职业培训不同的研究生。在化学系化学催化项目的资助下,密歇根大学的桑福德博士正在研究高价镍中间体[即镍(III)和镍(IV)络合物]的基础有机金属化学。尽管它们可能与许多重要的镍催化的交叉偶联和C-H官能化反应有关,但金属有机镍(III)和镍(IV)化合物的合成和反应活性尚未得到系统的研究。目前的工作重点是利用模型系统和催化中间体来确定镍(III)和镍(IV)中心各种转化的可行性和机制。这里建立的反应性和选择性分布有望对新的高价镍催化转化的设计和优化产生变革性的影响。桑福德博士还积极参与旨在扩大女性在K-12、本科生、研究生和教职员工层面参与科学的外联计划。此外,她的项目是在无机和有机合成、无机反应机理、电化学和催化等跨学科领域培训一批不同的科学家。一支训练有素及多元化的科研队伍,对二十一世纪创新科技的持续发展至为重要。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Experimental and Computational Studies of High-Valent Nickel and Palladium Complexes
- DOI:10.1021/acs.organomet.7b00613
- 发表时间:2017-11-27
- 期刊:
- 影响因子:2.8
- 作者:Camasso, Nicole M.;Canty, Allan J.;Sanford, Melanie S.
- 通讯作者:Sanford, Melanie S.
Nickel(II/IV) Manifold Enables Room-Temperature C(sp 3 )–H Functionalization
镍 (II/IV) 歧管可实现室温 C(sp 3 )–H 功能化
- DOI:10.1021/jacs.9b11999
- 发表时间:2019
- 期刊:
- 影响因子:15
- 作者:Roberts, Courtney C.;Chong, Eugene;Kampf, Jeff W.;Canty, Allan J.;Ariafard, Alireza;Sanford, Melanie S.
- 通讯作者:Sanford, Melanie S.
Connecting Organometallic Ni(III) and Ni(IV): Reactions of Carbon-Centered Radicals with High-Valent Organonickel Complexes
- DOI:10.1021/jacs.9b02411
- 发表时间:2019-06-05
- 期刊:
- 影响因子:15
- 作者:Bour, James R.;Ferguson, Devin M.;Sanford, Melanie S.
- 通讯作者:Sanford, Melanie S.
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Melanie Sanford其他文献
Melanie Sanford的其他文献
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{{ truncateString('Melanie Sanford', 18)}}的其他基金
CAS: Cu, Fe, and Ni Pincer Complexes: A Platform for Fundamental Mechanistic Investigations and Reaction Discovery
CAS:Cu、Fe 和 Ni 钳配合物:基础机理研究和反应发现的平台
- 批准号:
2349827 - 财政年份:2024
- 资助金额:
$ 45万 - 项目类别:
Continuing Grant
CAS: Organometallic Chemistry of Catalytically Relevant High Valent Nickel and Copper
CAS:催化相关高价镍和铜的有机金属化学
- 批准号:
1954985 - 财政年份:2020
- 资助金额:
$ 45万 - 项目类别:
Standard Grant
Organometallic Chemistry of High Valent Palladium, Nickel, and Copper
高价钯、镍和铜的有机金属化学
- 批准号:
1361542 - 财政年份:2014
- 资助金额:
$ 45万 - 项目类别:
Standard Grant
Organometallic Chemistry of High Oxidation State Palladium
高氧化态钯的有机金属化学
- 批准号:
1111563 - 财政年份:2011
- 资助金额:
$ 45万 - 项目类别:
Standard Grant
CAREER: Mechanistic Studies of Carbon-Heteroatom Bond-Forming Reactions in Oxidative Catalysis
职业:氧化催化中碳-杂原子成键反应的机理研究
- 批准号:
0545909 - 财政年份:2006
- 资助金额:
$ 45万 - 项目类别:
Continuing Grant
相似国自然基金
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Science China Chemistry
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- 项目类别:面上项目
相似海外基金
CAS: Organometallic Chemistry of High- and Low-Valent Nickel Centers
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2155160 - 财政年份:2022
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CAS: Organometallic Chemistry of Catalytically Relevant High Valent Nickel and Copper
CAS:催化相关高价镍和铜的有机金属化学
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RGPIN-2018-05531 - 财政年份:2020
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$ 45万 - 项目类别:
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Low-valent and low-coordinate main group chemistry
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RGPIN-2018-05531 - 财政年份:2019
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$ 45万 - 项目类别:
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Low-valent and low-coordinate main group chemistry
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- 批准号:
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$ 45万 - 项目类别:
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RGPIN-2018-05531 - 财政年份:2018
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