CAREER: Mechanistic Studies of Carbon-Heteroatom Bond-Forming Reactions in Oxidative Catalysis

这个由无机，生物无机和有机化学计划的职业奖支持密歇根大学安阿伯的Melanie Sanford教授的工作，研究高氧化态后过渡金属络合物的基本化学反应性，包括Pd（IV），Ni（III）和Ni（IV）的络合物。 拟议的研究将为金属中心的碳-杂原子键形成转化提供新的反应模式，这最终可能促进精细和/或商品化学品的工业合成。这项研究将集中在这些金属如何促进形成新化学键的反应的机理方面。 该奖项还支持开发和传播催化高级本科实验室实验的新模型。拟议的实验室实验将纳入该领域的现代方面（例如，烯烃复分解反应，2005年诺贝尔化学奖的主题），并旨在将学生从传统的实验室课程过渡到高度真实的研究型实验室体验。这种新的课程形式预计将增加本科生参与研究，并最终在科学的职业道路。此外，拟议的研究项目将提供广泛的培训，为不同的本科生和研究生在机械和合成无机化学。

This CAREER award by the Inorganic, Bioinorganic and Organometallic Chemistry program supports work by Professor Melanie Sanford at University of Michigan, Ann Arbor to study the fundamental chemical reactivity of high oxidation state late transition metal complexes including complexes of Pd(IV), Ni(III) and Ni(IV). The proposed studies will provide insights into new modes of reactivity for carbon-heteroatom bond-forming transformations at metal centers, which could ultimately facilitate the industrial synthesis of fine and/or commodity chemicals. This research will focus on mechanistic aspects of how these metals promote reactions that form of newchemical bonds. The award also supports the development and dissemination of a new model for advanced undergraduate laboratory experiments in catalysis. The proposed laboratory experiments will incorporate modern aspects of the field (for example, the olefin metathesis reaction, the subject of the 2005 Nobel Prize in Chemistry), and are designed to transition the students from a traditional laboratory course to a highly authentic research-like laboratory experience. This new course format is expected to increase undergraduate participation in research and ultimately in scientific career paths. Additionally, the proposed researchprojects will provide broad training for diverse undergraduate and graduate students inmechanistic and synthetic inorganic chemistry.