CAREER: Mechanistic Studies of Carbon-Heteroatom Bond-Forming Reactions in Oxidative Catalysis

由无机、生物无机和有机金属化学项目颁发的CAREER奖支持密歇根大学安娜堡分校Melanie Sanford教授对高氧化态晚期过渡金属配合物（包括Pd（IV）、Ni（III）和Ni（IV）配合物）的基本化学反应性的研究。提出的研究将为金属中心碳杂原子成键转化的新反应模式提供见解，这最终可能促进精细和/或商品化学品的工业合成。这项研究将集中在这些金属如何促进形成新化学键的反应的机制方面。该奖项还支持开发和传播一种新的模式，用于高等本科催化实验室实验。拟议的实验室实验将纳入该领域的现代方面（例如，2005年诺贝尔化学奖的主题烯烃再分解反应），并旨在将学生从传统的实验室课程过渡到高度真实的研究型实验室体验。这种新的课程形式有望增加本科生对研究的参与，并最终走上科学的职业道路。此外，拟议的研究项目将为机械和合成无机化学的本科生和研究生提供广泛的培训。

This CAREER award by the Inorganic, Bioinorganic and Organometallic Chemistry program supports work by Professor Melanie Sanford at University of Michigan, Ann Arbor to study the fundamental chemical reactivity of high oxidation state late transition metal complexes including complexes of Pd(IV), Ni(III) and Ni(IV). The proposed studies will provide insights into new modes of reactivity for carbon-heteroatom bond-forming transformations at metal centers, which could ultimately facilitate the industrial synthesis of fine and/or commodity chemicals. This research will focus on mechanistic aspects of how these metals promote reactions that form of newchemical bonds. The award also supports the development and dissemination of a new model for advanced undergraduate laboratory experiments in catalysis. The proposed laboratory experiments will incorporate modern aspects of the field (for example, the olefin metathesis reaction, the subject of the 2005 Nobel Prize in Chemistry), and are designed to transition the students from a traditional laboratory course to a highly authentic research-like laboratory experience. This new course format is expected to increase undergraduate participation in research and ultimately in scientific career paths. Additionally, the proposed researchprojects will provide broad training for diverse undergraduate and graduate students inmechanistic and synthetic inorganic chemistry.