Organometallic Chemistry of High Valent Palladium, Nickel, and Copper

高价钯、镍和铜的有机金属化学

• 批准号: 1361542
• 负责人: Melanie Sanford
• 金额: $ 49.5万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1361542&HistoricalAwards=false
• 关键词: Organometallic; Chemistry; Valent; Palladium; Nickel

In this project funded by the Chemical Catalysis program of the Chemistry Division, Professor Melanie Sanford of The University of Michigan focuses on the development of new catalysts that can ultimately be used for the synthesis of pharmaceuticals and agrochemicals via more efficient, direct, and environmentally friendly processes. To meet this challenge, the project will establish a more detailed scientific understanding of the challenging steps of the catalysis processes. In addition, new catalysts based on less toxic and earth abundant elements will be explored and developed. In addition, an outreach program led by Professor Sanford (UM FEMMES, Females Excelling More in Mathematics, Engineering, and Science) exposes middle school girls from Ann Arbor and surrounding communities to hands-on science activities. The broader impacts of this work include potential societal benefits from the discovery of more efficient catalysts and catalysts derived from less toxic, earth abundant metals. This project serves as a training ground for undergraduate and graduate students for careers at the interface of catalysis, inorganic and organic chemistry.The research focuses on detailed mechanistic studies of the challenging steps of the catalytic cycle, primarily alkyl-heteroatom bond-forming reductive elimination processes. Ligands will be designed to stabilize the reacting metal centers (high valent Pd, Ni, and Cu complexes) in order to investigate the scope, mechanism, and stereochemical outcomes of these processes.

在这个由化学部化学催化计划资助的项目中，密歇根大学的Melanie Sanford教授专注于开发新的催化剂，这些催化剂最终可用于通过更有效，直接和环保的工艺合成药物和农用化学品。为了迎接这一挑战，该项目将建立一个更详细的催化过程的挑战性步骤的科学认识。此外，将探索和开发基于毒性较小和地球丰富元素的新催化剂。此外，由桑福德教授（UM FEMMES，女性在数学，工程和科学方面更出色）领导的外展计划使来自安阿伯和周边社区的中学女生接触动手科学活动。这项工作的更广泛的影响包括发现更有效的催化剂和来自毒性较低、地球丰富的金属的催化剂的潜在社会效益。该项目是本科生和研究生在催化、无机和有机化学领域职业生涯的培训基地。该研究重点是催化循环中具有挑战性的步骤的详细机理研究，主要是烷基-杂原子键形成的还原消除过程。配体将被设计为稳定反应金属中心（高价钯，镍和铜络合物），以研究这些过程的范围，机制和立体化学结果。