Organometallic Chemistry of High Valent Palladium, Nickel, and Copper

在这个由化学系化学催化计划资助的项目中，密歇根大学的Melanie Sanford教授专注于开发新的催化剂，这些催化剂最终可以通过更高效、更直接和更环保的过程用于药物和农用化学品的合成。为了迎接这一挑战，该项目将对催化过程中具有挑战性的步骤建立更详细的科学理解。此外，还将探索和开发基于低毒和富含稀土元素的新型催化剂。此外，由桑福德教授(UM女性，女性更擅长数学、工程和科学)领导的一项外展计划让安娜堡和周边社区的中学女孩接触到实践科学活动。这项工作的更广泛影响包括发现更有效的催化剂和从毒性较低、富含稀土的金属中提取的催化剂的潜在社会效益。该项目作为本科生和研究生在催化、无机化学和有机化学领域就业的培训基地。研究重点是催化循环中具有挑战性的步骤的详细机理研究，主要是烷基杂原子键形成还原消除过程。为了研究这些过程的范围、机制和立体化学结果，将设计配体以稳定反应的金属中心(高价Pd、Ni和Cu络合物)。

In this project funded by the Chemical Catalysis program of the Chemistry Division, Professor Melanie Sanford of The University of Michigan focuses on the development of new catalysts that can ultimately be used for the synthesis of pharmaceuticals and agrochemicals via more efficient, direct, and environmentally friendly processes. To meet this challenge, the project will establish a more detailed scientific understanding of the challenging steps of the catalysis processes. In addition, new catalysts based on less toxic and earth abundant elements will be explored and developed. In addition, an outreach program led by Professor Sanford (UM FEMMES, Females Excelling More in Mathematics, Engineering, and Science) exposes middle school girls from Ann Arbor and surrounding communities to hands-on science activities. The broader impacts of this work include potential societal benefits from the discovery of more efficient catalysts and catalysts derived from less toxic, earth abundant metals. This project serves as a training ground for undergraduate and graduate students for careers at the interface of catalysis, inorganic and organic chemistry.The research focuses on detailed mechanistic studies of the challenging steps of the catalytic cycle, primarily alkyl-heteroatom bond-forming reductive elimination processes. Ligands will be designed to stabilize the reacting metal centers (high valent Pd, Ni, and Cu complexes) in order to investigate the scope, mechanism, and stereochemical outcomes of these processes.