Organometallic Chemistry of High Valent Palladium, Nickel, and Copper

在这个由化学部门化学催化项目资助的项目中，密歇根大学的Melanie Sanford教授专注于开发新的催化剂，这些催化剂最终可以通过更高效、直接和环保的过程用于合成药物和农用化学品。为了应对这一挑战，该项目将对催化过程中具有挑战性的步骤建立更详细的科学理解。此外，还将探索和开发以低毒性和富土元素为基础的新型催化剂。此外，由桑福德教授（UM FEMMES，女性在数学、工程和科学方面表现更出色）领导的外展计划让安娜堡和周边社区的中学女生参加动手科学活动。这项工作的更广泛的影响包括发现更有效的催化剂和从毒性较小的富土金属中提取的催化剂的潜在社会效益。该项目为本科生和研究生在催化、无机和有机化学界面的职业生涯提供了一个训练基地。研究重点是催化循环中具有挑战性的步骤的详细机理研究，主要是烷基-杂原子成键还原消除过程。为了研究这些过程的范围、机制和立体化学结果，将设计配体来稳定反应的金属中心（高价Pd、Ni和Cu配合物）。

In this project funded by the Chemical Catalysis program of the Chemistry Division, Professor Melanie Sanford of The University of Michigan focuses on the development of new catalysts that can ultimately be used for the synthesis of pharmaceuticals and agrochemicals via more efficient, direct, and environmentally friendly processes. To meet this challenge, the project will establish a more detailed scientific understanding of the challenging steps of the catalysis processes. In addition, new catalysts based on less toxic and earth abundant elements will be explored and developed. In addition, an outreach program led by Professor Sanford (UM FEMMES, Females Excelling More in Mathematics, Engineering, and Science) exposes middle school girls from Ann Arbor and surrounding communities to hands-on science activities. The broader impacts of this work include potential societal benefits from the discovery of more efficient catalysts and catalysts derived from less toxic, earth abundant metals. This project serves as a training ground for undergraduate and graduate students for careers at the interface of catalysis, inorganic and organic chemistry.The research focuses on detailed mechanistic studies of the challenging steps of the catalytic cycle, primarily alkyl-heteroatom bond-forming reductive elimination processes. Ligands will be designed to stabilize the reacting metal centers (high valent Pd, Ni, and Cu complexes) in order to investigate the scope, mechanism, and stereochemical outcomes of these processes.