ANTIBACTERIAL MINERAL MAPPING: A NEW ECONOMIC GEOLOGY

抗菌矿物测绘：新的经济地质学

• 批准号: 1123931
• 负责人: Lynda Williams
• 金额: $ 37.98万
• 依托单位: Arizona State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-10-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1123931&HistoricalAwards=false
• 关键词: ANTIBACTERIAL; MINERAL; MAPPING; NEW; ECONOMIC

With strong evidence from exploratory research supporting that certain natural clay minerals are effective antimicrobial agents, this research will examine the geological environment controlling formation and stability of antibacterial mineral deposits and further explore the antibacterial mechanism. The primary goal is to delineate the scientific basis by which natural clay minerals are able to kill bacteria and promote healing, therefore validating the use of natural clays as an economical treatment for bacterial infections. A detailed field map of antibacterial minerals in one deposit will be constructed to identify antibacterial zones. The mineralogy of this deposit will be compared to other antibacterial clay samples worldwide, with statistical analysis used to identify the principal components in common. Antibacterial testing of the identified mineralogical/geochemical components will be performed on Gram-negative and Gram-positive bacteria representative of common infectious diseases. The results could have broad-reaching applications in topical antimicrobial dressings; wound care management, personal care, and animal care markets. Using a variety of geochemical, mineralogical and microbiological approaches to assess the mineral-microbe interactions, our results will provide insights to the chemical conditions controlling the mineral induced bactericide. Finally, we will use ultra-high resolution (50nm) ion imaging (NanoSIMS) to show where biomolecules within a single cell are being altered by bactericidal reactions. These results may lead to new designs for controlling antibiotic-resistant infections and diseases for which there are no known therapeutic agents.

根据探索性研究的有力证据，某些天然粘土矿物是有效的抗菌剂，本研究将探讨控制抗菌矿床形成和稳定性的地质环境，并进一步探讨其抗菌机理。主要目标是阐明天然粘土矿物能够杀灭细菌和促进愈合的科学基础，从而验证使用天然粘土作为治疗细菌感染的经济方法。将建立一个矿床中抗菌矿物的详细野外地图，以确定抗菌带。该矿床的矿物学将与世界各地的其他抗菌粘土样品进行比较，并使用统计分析来确定共同的主要成分。将对代表常见传染病的革兰氏阴性和革兰氏阳性细菌进行已确定的矿物学/地球化学组分的抗菌测试。这一结果可能在局部抗菌敷料、伤口护理管理、个人护理和动物护理市场中具有广泛的应用。使用各种地球化学、矿物学和微生物学方法来评估矿物-微生物的相互作用，我们的结果将为控制矿物诱导杀菌剂的化学条件提供见解。最后，我们将使用超高分辨率(50 Nm)离子成像(NanoSIMS)来显示单个细胞内的生物分子正在被杀菌反应改变的位置。这些结果可能导致控制抗生素耐药性感染和尚无已知治疗剂的疾病的新设计。