CDI Type-II: Collaborative Research: From Ion Channels to Blood Flow and Heart Sounds: A New Paradigm in Cyber-Enabled Multiphysical Analysis of Heart Function

提出的研究的概念前提是，将新的建模和计算方法集成到心脏功能的分析中，将使在不久的将来能够开发变革性的仿真指导分析工具，以表征心脏功能。该项目的目标是开发在大型异构计算机系统上高效运行的正常和异常心脏心室的多物理模型。研究的重点是将这些计算工具应用于健康的心脏，以及心律失常或其他疾病的心脏。这项工作的一个新颖方面包括心音的直接计算，这将显著推进舒张功能障碍的非侵入性诊断。除了心脏功能和心脏病，研究的影响延伸到计算生物物理学，生物力学，计算机工程和流体力学领域，以及其他器官系统。这项研究将为正常和患病心脏的机电/血流动力学建模提供一系列综合仿真工具，通过有效的数据管理，将这些工具提供给更广泛的社区。学生和博士后的研究培训将有助于培养新一代的科学家和工程师，他们可以跨越学科界限应用计算思维。私人行政区内的教育影响？大学将通过将研究成果转化为新的和现有的课程而得到加强；将通过计划中的高中和以少数民族为重点的外联活动，在警察机构以外产生影响。

The conceptual premise of the proposed research is that integrating new modeling and computational approaches into the analysis of heart function will enable the development of transformative simulation-guided analytical tools for characterizing heart function in the not-too-distant future. The goal of the project is to develop multi-physics models of ventricles in normal and abnormal hearts that run efficiently on large-scale, heterogeneous computer systems. The research will focus on applying these computational tools to healthy hearts and also to those with arrhythmia or other disorders. One novel aspect of the work incorporates the direct computation of heart sounds which should significantly advance non-invasive diagnosis of diastolic dysfunction. Beyond cardiac function and heart disease, the impact of the research extends to the areas of computational biophysics, biomechanics, computer engineering and fluid mechanics, as well as to other organ systems. The research will produce an integrated array of simulation tools for electromechanical/hemodynamical modeling in normal and diseased hearts that will be made available to the broader community though effective data management. Research training of students and postdocs will contribute to a new generation of scientists and engineers who can apply computational thinking across disciplinary boundaries. Educational impact within the PIs? universities will be enhanced by translating the research into new and existing courses; impact outside the PIs institutions will be achieved via planned high-school and minority-focused outreach activities.