CDI Type-II: Collaborative Research: From Ion Channels to Blood Flow and Heart Sounds: A New Paradigm in Cyber-Enabled Multiphysical Analysis of Heart Function

CDI II 型：协作研究：从离子通道到血流和心音：网络支持的心脏功能多物理分析的新范式

• 批准号: 1124804
• 负责人: Rajat Mittal
• 金额: $ 145万
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2016-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1124804&HistoricalAwards=false
• 关键词: CDI; Type; II; Collaborative; Research

The conceptual premise of the proposed research is that integrating new modeling and computational approaches into the analysis of heart function will enable the development of transformative simulation-guided analytical tools for characterizing heart function in the not-too-distant future. The goal of the project is to develop multi-physics models of ventricles in normal and abnormal hearts that run efficiently on large-scale, heterogeneous computer systems. The research will focus on applying these computational tools to healthy hearts and also to those with arrhythmia or other disorders. One novel aspect of the work incorporates the direct computation of heart sounds which should significantly advance non-invasive diagnosis of diastolic dysfunction. Beyond cardiac function and heart disease, the impact of the research extends to the areas of computational biophysics, biomechanics, computer engineering and fluid mechanics, as well as to other organ systems. The research will produce an integrated array of simulation tools for electromechanical/hemodynamical modeling in normal and diseased hearts that will be made available to the broader community though effective data management. Research training of students and postdocs will contribute to a new generation of scientists and engineers who can apply computational thinking across disciplinary boundaries. Educational impact within the PIs? universities will be enhanced by translating the research into new and existing courses; impact outside the PIs institutions will be achieved via planned high-school and minority-focused outreach activities.

拟议研究的概念前提是，将新的建模和计算方法集成到心脏功能分析中，将能够在不久的将来开发用于表征心脏功能的变革性模拟引导分析工具。该项目的目标是开发正常和异常心脏心室的多物理模型，这些模型可以在大规模异构计算机系统上有效运行。这项研究将集中于将这些计算工具应用于健康的心脏以及心律失常或其他疾病的患者。这项工作的一个新的方面是直接计算心音，这将大大推进舒张功能障碍的非侵入性诊断。除了心脏功能和心脏病，研究的影响还扩展到计算生物物理学，生物力学，计算机工程和流体力学以及其他器官系统。该研究将产生一系列完整的模拟工具，用于正常和患病心脏的机电/血液动力学建模，通过有效的数据管理，这些工具将提供给更广泛的社区。对学生和博士后的研究培训将为新一代能够跨越学科界限应用计算思维的科学家和工程师做出贡献。对PI的教育影响？将通过将研究成果转化为新的和现有的课程来加强对大学的影响;将通过计划中的高中和以少数民族为重点的外联活动来实现对PI机构以外的影响。