EAGER: Brain Responses to Visual Stimuli in Sharks Using Functional Magnetic Resonance Imaging (FMRI)

EAGER：使用功能磁共振成像 (FMRI) 观察鲨鱼的大脑对视觉刺激的反应

基本信息

批准号：
1143389
负责人：
Lawrence Frank
金额：
$ 25万
依托单位：
University of California-San Diego
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-15 至 2014-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1143389&HistoricalAwards=false
关键词：
EAGER Brain Responses Visual Stimuli

项目摘要

The University of California at San Diego is awarded a grant to develop methods for performing functional magnetic resonance imaging (FMRI) experiments in living sharks in order to study their brains as a complete neural network and provide information on how vertebrate neural systems have both structurally and functionally evolved. Understanding this organization and its relationship to shark behavior and ecology has major implications for our understanding of the evolution of vertebrate nervous systems, and the relationship between form and function in the vertebrate brain. In recent years, great advances in human neuroscience have been made using FMRI, where localized changes in brain activity are detected within a sequence of MR images, thus allowing brain activation as a function of time to be measured. In conjunction with advanced methods for non-invasive, high-resolution MRI for quantitating form in chondrichthyan brains, the goal of this project is to develop FMRI capabilities that facilitate the study of the relationship between form and function in these fishes. However, while FMRI in humans is now routine, performing it in sharks requires the development and refinement of both software and hardware to collect reliable, high quality anatomical and functional MRI data in a living partially submerged aquatic specimen. Hence our key objective is to develop these technological advances, and demonstrate the capability of performing FMRI experiments in the shark nervous system. This project will provide a unique set of methods for studying the relationships between form and function in the shark nervous system, as well as other aquatic model systems, and thus has broad implications for many researchers for whom the link between morphology and function is of great importance, but difficult to explore simultaneously in a well-controlled experimental platform. This project also promotes interdisciplinary collaboration and training in imaging, computation, and data analysis for the morphology, physiology, and marine biology communities. The outcomes of this award including methods, equipment design, and data analysis software will be disseminated to the research community through the Digital Fish Library website (http://www.digitalfishlibrary.org).

加利福尼亚大学圣地亚哥分校获得了一项赠款，以开发在活鲨中执行功能性磁共振成像（fMRI）实验的方法，以便将其大脑作为一个完整的神经网络研究，并提供有关脊椎动物神经系统在结构和功能上如何发展的信息。了解该组织及其与鲨鱼行为和生态学的关系对我们对脊椎动物神经系统的演变以及脊椎动物大脑中形式和功能之间的关系具有重大影响。近年来，使用fMRI在人类神经科学方面取得了巨大进步，在MR图像序列中检测到脑活动的局部变化，从而使大脑激活是可以测量时间的函数。结合用于量化Chondrichthyan大脑的非侵入性高分辨率MRI的高级方法，该项目的目标是开发功能障碍能力，以促进研究这些鱼类形式与功能之间关系的研究。但是，尽管人类的fMRI现在是常规的，但在鲨鱼中执行它需要软件和硬件的开发和完善，以在部分淹没的水生标本中收集可靠，高质量的解剖和功能性MRI数据。因此，我们的主要目标是开发这些技术进步，并证明在鲨鱼神经系统中进行fMRI实验的能力。该项目将提供一组独特的方法，用于研究鲨鱼神经系统中形式和功能之间的关系以及其他水生模型系统，因此对许多研究人员具有广泛的影响，这些研究人员对它们的形态和功能之间的联系非常重要，但很难同时在一个良好的控制实验平台中同时探索。该项目还促进了形态，生理学和海洋生物学社区的成像，计算和数据分析方面的跨学科合作和培训。该奖项的结果包括方法，设备设计和数据分析软件将通过数字鱼图书馆网站（http://www.digitalfishlibrary.org）传播到研究社区。