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EAGER: Brain Responses to Visual Stimuli in Sharks Using Functional Magnetic Resonance Imaging (FMRI)

EAGER：使用功能磁共振成像 (FMRI) 观察鲨鱼的大脑对视觉刺激的反应

基本信息

批准号：
1143389
负责人：
Lawrence Frank
金额：
$ 25万
依托单位：
University of California-San Diego
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-15 至 2014-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1143389&HistoricalAwards=false
关键词：
EAGER Brain Responses Visual Stimuli

项目摘要

The University of California at San Diego is awarded a grant to develop methods for performing functional magnetic resonance imaging (FMRI) experiments in living sharks in order to study their brains as a complete neural network and provide information on how vertebrate neural systems have both structurally and functionally evolved. Understanding this organization and its relationship to shark behavior and ecology has major implications for our understanding of the evolution of vertebrate nervous systems, and the relationship between form and function in the vertebrate brain. In recent years, great advances in human neuroscience have been made using FMRI, where localized changes in brain activity are detected within a sequence of MR images, thus allowing brain activation as a function of time to be measured. In conjunction with advanced methods for non-invasive, high-resolution MRI for quantitating form in chondrichthyan brains, the goal of this project is to develop FMRI capabilities that facilitate the study of the relationship between form and function in these fishes. However, while FMRI in humans is now routine, performing it in sharks requires the development and refinement of both software and hardware to collect reliable, high quality anatomical and functional MRI data in a living partially submerged aquatic specimen. Hence our key objective is to develop these technological advances, and demonstrate the capability of performing FMRI experiments in the shark nervous system. This project will provide a unique set of methods for studying the relationships between form and function in the shark nervous system, as well as other aquatic model systems, and thus has broad implications for many researchers for whom the link between morphology and function is of great importance, but difficult to explore simultaneously in a well-controlled experimental platform. This project also promotes interdisciplinary collaboration and training in imaging, computation, and data analysis for the morphology, physiology, and marine biology communities. The outcomes of this award including methods, equipment design, and data analysis software will be disseminated to the research community through the Digital Fish Library website (http://www.digitalfishlibrary.org).

加州大学圣地亚哥分校获得了一项拨款，用于开发在活体鲨鱼身上进行功能磁共振成像 (FMRI) 实验的方法，以将其大脑作为一个完整的神经网络进行研究，并提供有关脊椎动物神经系统在结构和功能上如何进化的信息。了解这种组织及其与鲨鱼行为和生态的关系对于我们理解脊椎动物神经系统的进化以及脊椎动物大脑的形式和功能之间的关系具有重大意义。近年来，人类神经科学利用 FMRI 取得了巨大进步，在一系列 MR 图像中检测到大脑活动的局部变化，从而可以测量大脑活动随时间的变化。结合用于定量软骨鱼类大脑形态的非侵入性高分辨率 MRI 的先进方法，该项目的目标是开发 FMRI 功能，以促进这些鱼类形态与功能之间关系的研究。然而，虽然现在对人类进行 FMRI 已成为常规，但在鲨鱼身上进行 FMRI 需要开发和完善软件和硬件，以便在部分浸没的活体水生标本中收集可靠、高质量的解剖和功能 MRI 数据。因此，我们的主要目标是开发这些技术进步，并展示在鲨鱼神经系统中进行 FMRI 实验的能力。该项目将为研究鲨鱼神经系统以及其他水生模型系统的形式和功能之间的关系提供一套独特的方法，因此对许多研究人员具有广泛的意义，对他们来说，形态和功能之间的联系非常重要，但很难在控制良好的实验平台中同时探索。该项目还促进形态学、生理学和海洋生物学界在成像、计算和数据分析方面的跨学科合作和培训。该奖项的成果，包括方法、设备设计和数据分析软件，将通过数字鱼类图书馆网站（http://www.digitalfishlibrary.org）向研究界传播。