The Role of Endoreduplication in Mitigating the Detrimental Effects of Herbivory

内复制在减轻食草动物有害影响中的作用

基本信息

  • 批准号:
    1146085
  • 负责人:
  • 金额:
    $ 44万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-02-15 至 2018-01-31
  • 项目状态:
    已结题

项目摘要

Endoreduplication is the replication of the genome without mitosis, which leads to endopolyploidy, an increase in cellular chromosome number. The process of endoreduplication occurs in nearly all herbaceous flowering plants, yet its primary function is unknown. Here Dr. Paige proposes to test a novel idea - that chromosome amplification can mitigate the detrimental effects of herbivory and lead to enhanced growth and reproduction. Previous studies by the Paige lab have shown a correlation between chromosome amplification, plant reproduction and herbivory, however, no direct causal links have been established. To establish a causal relationship he will use a suite of greenhouse and field studies to generalize the phenomenon within two species of plants, Arabidopsis thaliana and Ipomopsis aggregata, assess whether ILP1, a gene that regulates chromosome amplification, correlates with reproductive success following herbivory in A. thaliana and use knockout and overexpression mutants of ILP1 to establish a causal relationship between chromosome amplification, herbivory and reproductive success.If chromosome amplification leads to enhanced reproduction, such changes may be of an adaptive nature and widespread among plants in mitigating the detrimental effects of herbivory. Furthermore, gaining an understanding of the genetic basis of increased seed yield following herbivore damage should be of great interest to agriculturists who, through recent advents in genetic technology, might incorporate traits (such as ILP1 overexpression promoters) into crop plants such as oilseed rape (Brassica napus), a close relative of Arabidopsis that also amplifies chromosome number. He also suspects that these studies reach far beyond the interactions between plants and herbivores and may in fact represent a generalized response to all kinds of environmental stressors.
核内复制是基因组在没有有丝分裂的情况下复制,这导致核内多倍性,细胞染色体数目的增加。 核内复制的过程发生在几乎所有的草本开花植物,但其主要功能是未知的。 在这里,Paige博士提出了一个新的想法-染色体扩增可以减轻草食动物的有害影响,并导致增强的生长和繁殖。 Paige实验室以前的研究表明,染色体扩增、植物繁殖和食草动物之间存在相关性,但尚未建立直接的因果关系。 为了建立因果关系,他将使用一套温室和田间研究来概括两种植物(拟南芥和Ipomopsis aggregata)中的现象,评估ILP 1(一种调节染色体扩增的基因)是否与A. thaliana和利用ILP 1的敲除和过表达突变体来建立染色体扩增、植食性和繁殖成功之间的因果关系。如果染色体扩增导致增强的繁殖,这种变化可能具有适应性,并且在植物中广泛存在,以减轻植食性的不利影响。 此外,了解草食动物损害后种子产量增加的遗传基础应该引起农业学家的极大兴趣,他们通过遗传技术的最新进展,可能会将性状(如ILP 1过表达启动子)纳入作物植物,如油菜(甘蓝型油菜),拟南芥的近亲,也会扩增染色体数目。 他还怀疑这些研究远远超出了植物和食草动物之间的相互作用,实际上可能代表了对各种环境压力的普遍反应。

项目成果

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Ken Paige其他文献

Ken Paige的其他文献

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{{ truncateString('Ken Paige', 18)}}的其他基金

DISSERTATION RESEARCH: The genetic basis of endoreduplication and fitness compensation in plants
论文研究:植物核内复制和适应性补偿的遗传基础
  • 批准号:
    1308941
  • 财政年份:
    2013
  • 资助金额:
    $ 44万
  • 项目类别:
    Standard Grant
EAGER: Somatic Mutations in Plants
EAGER:植物体细胞突变
  • 批准号:
    1010868
  • 财政年份:
    2010
  • 资助金额:
    $ 44万
  • 项目类别:
    Standard Grant
DISSERTATION RESEARCH: Demographic and Biogeographic History of Deciduous Forest Vertebrates of the Central United States
论文研究:美国中部落叶林脊椎动物的人口统计和生物地理学历史
  • 批准号:
    0422957
  • 财政年份:
    2004
  • 资助金额:
    $ 44万
  • 项目类别:
    Standard Grant
Collaborative Research: The Evolution of Tolerance to Herbivory among Populations of Scarlet Gilia, Ipomopsis aggregata
合作研究:Scarlet Gilia、Ipomopsis aggregata 种群对草食性耐受性的进化
  • 批准号:
    0092554
  • 财政年份:
    2001
  • 资助金额:
    $ 44万
  • 项目类别:
    Continuing Grant
Dissertation Research: Predicting the Demography & Short- term Evolution of Arabidopsis Thaliana in Response to Increased UV-B Radiation
论文研究:预测人口统计
  • 批准号:
    9412068
  • 财政年份:
    1994
  • 资助金额:
    $ 44万
  • 项目类别:
    Standard Grant
Overcompensation in Response to Mammalian Herbivory: Measure of True Fitness, Alternative Selection Pressures, Compara- tive Responses, and the Genetics of Overcompensation
对哺乳动物食草反应的过度补偿:真实适应性的测量、替代选择压力、比较反应和过度补偿的遗传学
  • 批准号:
    8917556
  • 财政年份:
    1990
  • 资助金额:
    $ 44万
  • 项目类别:
    Continuing Grant
Collaborative Research: Hybrid Plants and Zones as 'Sinks' for Herbivores: A Model System for Intergrating Ecology, Genetics and Physiology of a Plant Herbivore Interaction
合作研究:作为食草动物“汇”的杂交植物和区域:植物食草动物相互作用的生态学、遗传学和生理学整合模型系统
  • 批准号:
    8907686
  • 财政年份:
    1989
  • 资助金额:
    $ 44万
  • 项目类别:
    Continuing Grant

相似海外基金

Progress of endoreduplication in the developing endosperm of rice (Oryza sativa)
水稻胚乳发育中核内复制的研究进展
  • 批准号:
    26850010
  • 财政年份:
    2014
  • 资助金额:
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  • 项目类别:
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DISSERTATION RESEARCH: The genetic basis of endoreduplication and fitness compensation in plants
论文研究:植物核内复制和适应性补偿的遗传基础
  • 批准号:
    1308941
  • 财政年份:
    2013
  • 资助金额:
    $ 44万
  • 项目类别:
    Standard Grant
Analysis of molecular mechanisms of endoreduplication through chloroplast-dependent regulation.
通过叶绿体依赖性调节分析核内复制的分子机制。
  • 批准号:
    19770044
  • 财政年份:
    2007
  • 资助金额:
    $ 44万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Factors and functions for endoreduplication in the C. elegans intestine
线虫肠道内复制的因素和功能
  • 批准号:
    301340-2004
  • 财政年份:
    2005
  • 资助金额:
    $ 44万
  • 项目类别:
    Postdoctoral Fellowships
Factors and functions for endoreduplication in the C. elegans intestine
线虫肠道内复制的因素和功能
  • 批准号:
    301340-2004
  • 财政年份:
    2004
  • 资助金额:
    $ 44万
  • 项目类别:
    Postdoctoral Fellowships
Collaborative Research: Life History Variation in Copepods: Modulation through Chromatin Diminution and Endoreduplication
合作研究:桡足类生活史变异:通过染色质减少和内复制进行调节
  • 批准号:
    0080921
  • 财政年份:
    2000
  • 资助金额:
    $ 44万
  • 项目类别:
    Standard Grant
Collaborative Research: Life History Variation in Copepods: Modulation through Chromatin Diminution and Endoreduplication
合作研究:桡足类生活史变异:通过染色质减少和内复制进行调节
  • 批准号:
    0084854
  • 财政年份:
    2000
  • 资助金额:
    $ 44万
  • 项目类别:
    Standard Grant
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