NDR1: A Point of Convergence in Stress and Pathogen Signaling in Arabidopsis Thaliana.

NDR1：拟南芥应激和病原体信号传导的汇聚点。

• 批准号: 1146128
• 负责人: Robert Day
• 金额: $ 70.79万
• 依托单位: Michigan State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1146128&HistoricalAwards=false
• 关键词: NDR1; Point; Convergence; Stress; Pathogen

Plants are constantly exposed to stress, yet they have evolved numerous mechanisms to respond, adapt, and thrive under some of the most hostile conditions. In most cases, the ability to adapt to stress, whether from the environment (abiotic) or predators (biotic), simply requires a "reallocation of resources". For example, under conditions of drought, plants down-regulate growth and development, both being energy-expensive processes, in favor of minimizing water loss. Similarly, when plants are infected by pathogens, the primary goal is to restrict pathogen access to nutrients. This project seeks to understand how plants utilize basic physiological processes to respond to stress. To do this, the project will investigate how biotic stress signaling is activated and regulated, and moreover, how this signaling process is interlinked with general host physiology and plant health. The principal investigator hypothesizes that in a manner similar to humans, plants utilize mechanisms to integrate environmental and pathogen-related stress signaling responses. The goal of this project is to understand how abiotic and biotic stress signaling is co-regulated, and to develop a model of how plants sense the world around them, process these perceived stimuli, and ultimately, survive under a variety of stress conditions. The impact of this work links basic plant health to environment, threats from pathogens, and in total, food security.The project includes an extensive outreach component. In short, a teaching module will be conducted by graduate and post-doctoral researchers in principal investigator's lab and carried out in collaboration with the Michigan State University Children's Garden and 4H Outreach Program. The major focus will be to educate elementary school children on the relationship(s) between environment, plant health, food, and sustainability. The goal of this outreach is to increase the awareness and understanding of young people of how food, and ultimately human health, is impacted by the environment, and moreover, to illustrate how humans impact the environment.

植物不断面临压力，但它们已经进化出许多机制来在一些最恶劣的条件下做出反应、适应和茁壮成长。在大多数情况下，适应压力的能力，无论是来自环境（非生物）还是捕食者（生物）的压力，只需要“重新分配资源”。例如，在干旱条件下，植物会下调生长和发育（这两个过程都是能源昂贵的过程），有利于最大限度地减少水分流失。同样，当植物被病原体感染时，首要目标是限制病原体获取营养。该项目旨在了解植物如何利用基本生理过程来应对压力。为此，该项目将研究生物胁迫信号如何被激活和调节，此外，该信号过程如何与一般宿主生理学和植物健康相互关联。主要研究人员假设，植物以与人类相似的方式利用机制来整合环境和病原体相关的应激信号反应。该项目的目标是了解非生物和生物胁迫信号如何共同调节，并开发一个模型来了解植物如何感知周围的世界，处理这些感知到的刺激，并最终在各种胁迫条件下生存。这项工作的影响将基本植物健康与环境、病原体的威胁以及粮食安全联系起来。该项目包括广泛的外展部分。简而言之，教学模块将由研究生和博士后研究人员在首席研究员实验室进行，并与密歇根州立大学儿童花园和 4H 外展计划合作进行。主要重点是教育小学生了解环境、植物健康、食品和可持续性之间的关系。此次宣传活动的目标是提高年轻人对环境如何影响食品以及最终人类健康的认识和理解，并说明人类如何影响环境。