MRI: Acquisition of Laser Capture Microdissection Instrumentation for Michigan State University

MRI：为密歇根州立大学采购激光捕获显微切割仪器

• 批准号: 0923149
• 负责人: Robert Day
• 金额: $ 21.18万
• 依托单位: Michigan State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0923149&HistoricalAwards=false
• 关键词: MRI; Acquisition; Laser; Capture; Microdissection

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).The study of plant biology has advanced our understanding in areas not only related to agriculture and food quality, but also in the areas of human biology. Recent advances in technologies in the area of biochemistry, cell biology and genetics have enabled plant scientists to address biological questions previously unattainable. This award provides support for the acquisition of a laser capture microdissection (LCM) system and ancillary equipment for advanced histologic analysis of plant materials at Michigan State University. LCM is an advanced method for analyzing single cells in living multicellular organisms. Using this technique, cells from a target microscopic region can be selected, isolated, and analyzed. In short, this yields precise cellular snapshots of cell diversity and the mechanisms controlling processes as varied as development, stress, metabolism, pathogenesis, and senescence. As a world leader in the experimental plant sciences, MSU is extremely well placed to use and disseminate this powerful technology, and the addition of LCM will leverage existing technological strengths at MSU to catalyze breakthroughs in plant biology. In addition, through hands-on training and education, post-graduate, graduate, undergraduate and even high school students will receive specialized training using LCM, as well as downstream genomic and proteomic techniques at MSU.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。植物生物学的研究不仅提高了我们对农业和食品质量领域的理解，而且也提高了我们对人类生物学领域的理解。 生物化学、细胞生物学和遗传学领域技术的最新进展使植物科学家能够解决以前无法解决的生物学问题。该奖项为密歇根州立大学的激光捕获显微切割（LCM）系统和辅助设备的采购提供支持，用于植物材料的高级组织学分析。 LCM是一种用于分析活多细胞生物中单细胞的先进方法。使用这种技术，可以选择、分离和分析来自目标显微区域的细胞。 简而言之，这产生了细胞多样性的精确细胞快照和控制过程的机制，如发育，应激，代谢，发病机制和衰老。 作为实验植物科学的世界领导者，密歇根州立大学非常适合使用和传播这种强大的技术，LCM的加入将利用密歇根州立大学现有的技术优势，促进植物生物学的突破。 此外，通过实践培训和教育，研究生，研究生，本科生甚至高中生将在MSU接受使用LCM以及下游基因组学和蛋白质组学技术的专业培训。