Ecological divergence along the early neuraxes

早期神经轴的生态分歧

• 批准号: 1146275
• 负责人: Jeffrey Streelman
• 金额: $ 50万
• 依托单位: Georgia Tech Research Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-01 至 2016-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1146275&HistoricalAwards=false
• 关键词: Ecological; divergence; along; early; neuraxes

Biologists know a great deal about how the process of development makes a brain, but less about the mechanisms employed during the evolution of brain diversity. The proposed research integrates the disciplines of ecology, evolutionary genetics and molecular biology to determine how some of the earliest events in an organism's lifetime lead to differences in brain organization, and ultimately to differences in behavior. Expected outcomes include the identification of developmental signaling pathways that organize embryonic brains and the means by which changes in these pathways drive ecologically relevant brain diversification. Broader impacts include (i) an integrative understanding of the relationship between animal development and behavior, (ii) the training of female and science-minority postdoctoral scientists, and (iii) creative educational programs for inner city Atlanta elementary schools.

生物学家对发育过程如何形成大脑知道很多，但对大脑多样性进化过程中使用的机制知之甚少。这项拟议的研究整合了生态学、进化遗传学和分子生物学的学科，以确定生物体生命中最早的一些事件如何导致大脑组织的差异，并最终导致行为的差异。预期的结果包括确定组织胚胎大脑的发育信号通路，以及这些通路的变化如何推动与生态相关的大脑多样化。更广泛的影响包括(I)对动物发育和行为之间的关系的综合理解，(Ii)女性和科学少数族裔博士后科学家的培训，以及(Iii)亚特兰大市中心小学的创造性教育计划。