Interactions of single polymer chains in a thermophoretic trap (B10)

这个项目的目的是通过对蛋白质原纤维生长的微观研究来帮助理解淀粉样蛋白的形成。在发展的热光捕获和荧光成像技术的基础上，我们的目标是在空间上限制单个种子纤维，以便直接实时地成像它们的生长、分支或碎裂以及它对蛋白质结构和其他影响纤维生长的成分的依赖。这将为文献中的动力学模型提供微观基础。

The aim of this project is to contribute with microscopic studies of the protein fibril growth to the understanding of amyloid formation. Building on the developed technique of thermo-phoretic trapping and fluorescence imaging we aim to constrain single seed fibrils spatially to directly image in real time their growth, branching or fragmentation and its dependence on the protein structure and other ingredients modifying the fibril growth. This shall provide a microscopic foundation for the kinetic models in the literature.