CAREER: Novel Voltammetric Biosensor Design to Promote Interest and Inquiry-Based Learning in Electrochemistry

职业：新型伏安生物传感器设计，促进电化学兴趣和探究式学习

• 批准号: 1151264
• 负责人: Leslie Sombers
• 金额: $ 60万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-15 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1151264&HistoricalAwards=false
• 关键词: CAREER; Novel; Voltammetric; Biosensor; Design

In this CAREER award, funded by the Chemical Measurement and Imaging Program of the Division of Chemistry, Professor Leslie Sombers of North Carolina State University and her graduate student researchers will be supported to investigate the use of fast-scan cyclic voltammetry to monitor the enzymatic generation of hydrogen peroxide with carbon-fiber microelectrodes. The approach that Prof. Sombers and her students are developing will be used to measure the presence and dynamics of specific, non-electroactive analytes in biological tissue. For her integrated educational project, Prof. Sombers will work with her students to develop a presentation to be given to the public at the North Carolina Museum of Science on the use of electrochemistry, as well as working with North Carolina State's Science House on developing hands-on materials for use in K-12 education. In situ detection of biologically active molecules is important in helping to innovate in biology, neuroscience and medicine. The kind of work that Prof. Sombers and her students are developing will allow researchers in these fields to make chemical measurements in relatively un-perturbed living systems. This is important in answering fundamental questions that can lead to new understandings of the operations of living systems, as well as developing new approaches to medicine. The graduate students working on this project will gain useful inter-disciplinary experience at the intersection of biology, chemistry and electronics. Prof. Sombers will also continue her efforts at increasing the opportunities for students from underrepresented groups to participate in the STEM enterprise.

在这个职业奖，由化学部的化学测量和成像计划资助，教授莱斯利Sombers的北卡罗来纳州州立大学和她的研究生研究人员将支持调查使用快速扫描循环伏安法监测过氧化氢的酶生成与碳纤维微电极。 Sombers教授和她的学生正在开发的方法将用于测量生物组织中特定的非电活性分析物的存在和动力学。 对于她的综合教育项目，Sombers教授将与她的学生合作，在北卡罗来纳州科学博物馆向公众介绍电化学的使用，并与北卡罗来纳州的科学之家合作开发用于K-12教育的实践材料。 生物活性分子的原位检测对于帮助生物学、神经科学和医学的创新非常重要。 Sombers教授和她的学生正在开发的工作将使这些领域的研究人员能够在相对不受干扰的生命系统中进行化学测量。 这对于回答基本问题非常重要，这些问题可以导致对生命系统运作的新理解，以及开发新的医学方法。 从事该项目的研究生将在生物学，化学和电子学的交叉点获得有用的跨学科经验。 Sombers还将继续努力增加来自代表性不足群体的学生参与STEM企业的机会。