CAREER: Control of Self-Assembly and Electrostatics with Photolabile Polymers

职业:用不稳定性聚合物控制自组装和静电

基本信息

  • 批准号:
    1151385
  • 负责人:
  • 金额:
    $ 50万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-03-01 至 2018-02-28
  • 项目状态:
    已结题

项目摘要

TECHNICAL SUMMARYCurrent limitations in the preparation and utilization of photoresponsive moieties have inhibited the development of enabling technologies that use the advantages of light-responsive polymers in new ways. The research objective of this award is to develop polymeric materials that have new photoresponsive properties because of the inclusion of photolabile groups, such as the o-nitrobenzylester (NBE) moiety. The central hypothesis of this research is that rational design of polymers with photolabile groups will enable photochemical control over the non-covalent intermolecular forces governed by hydrophobicity and charge-charge interactions. This research will focus on three classes of new light-responsive polymeric systems: 1) new block copolymers designed to switch from hydrophobic to hydrophilic, 2) layer-by-layer (LbL) polyelectrolyte films that switch interlayer electrostatic forces from attractive to repulsive, and 3) surface-bound polymeric coatings that switch the sign of the zeta potential. The proposed work is significant because it combines polymer synthesis and photochemistry to control intermolecular forces, resulting in new approaches to control matter with light. Expected outcomes of this research include polymers that photo-assemble into and disassemble from micelles, LbL films that are photopatternable in three dimensions, and coatings that enable photochemical control over electroosmotic fluid flow and static charging. These outcomes have potential applications in: 1) photochemically-labile carriers for targeted delivery, 2) all-aqueous photolithography, 3) photo-controlled microfluidic devices, and 4) photochemical control over the static charging of insulators. NON-TECHNICAL SUMMARYMaterials that respond to light have major technological importance, with applications ranging from human health (e.g. imaging agents and photochemical delivery of therapeutic agents) to microprocessor fabrication (e.g. high-resolution patterning of polymers in photolithography). The proposed interdisciplinary research will develop polymers that respond to light in new ways with both fundamental and applied implications. The proposed work also integrates this research with education through two new programs: 1) encouraging STEM careers by involving a local community college in scientific research; 2) a high school science fair mentoring program.
技术概要目前光响应部分的制备和利用方面的限制阻碍了以新方式利用光响应聚合物的优势的技术的发展。 该奖项的研究目标是开发由于包含邻硝基苯甲酯(NBE)部分等光不稳定基团而具有新光响应特性的聚合物材料。 这项研究的中心假设是,具有光不稳定基团的聚合物的合理设计将使光化学控制由疏水性和电荷-电荷相互作用控制的非共价分子间力成为可能。 这项研究将重点关注三类新型光响应聚合物系统:1)旨在从疏水性转变为亲水性的新型嵌段共聚物,2)将层间静电力从吸引力转变为排斥力的逐层(LbL)聚电解质薄膜,以及3)将zeta电位符号转变的表面结合聚合物涂层。 这项工作意义重大,因为它结合了聚合物合成和光化学来控制分子间力,从而产生了用光控制物质的新方法。 这项研究的预期成果包括通过光组装成胶束和从胶束中分解的聚合物、可在三个维度上光图案化的 LbL 薄膜,以及能够对电渗流体流动和静电进行光化学控制的涂层。 这些成果在以下方面具有潜在的应用:1)用于靶向递送的光化学不稳定载体,2)全水光刻,3)光控微流体装置,以及4)对绝缘体静电的光化学控制。 非技术摘要对光做出响应的材料具有重大的技术重要性,其应用范围从人类健康(例如显像剂和治疗剂的光化学递送)到微处理器制造(例如光刻中聚合物的高分辨率图案化)。 拟议的跨学科研究将开发以新方式响应光的聚合物,具有基础和应用意义。 拟议的工作还通过两个新计划将这项研究与教育结合起来:1)通过让当地社区大学参与科学研究来鼓励 STEM 职业; 2)高中科学博览会指导计划。

项目成果

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Samuel Thomas其他文献

Leaf respiration and alternative oxidase in field-grown alpine grasses respond to natural changes in temperature and light.
田间种植的高山草的叶子呼吸和替代氧化酶对温度和光照的自然变化做出反应。
  • DOI:
    10.1111/j.1469-8137.2010.03557.x
  • 发表时间:
    2011
  • 期刊:
  • 影响因子:
    0
  • 作者:
    S. Searle;Samuel Thomas;K. Griffin;T. Horton;A. Kornfeld;D. Yakir;V. Hurry;M. Turnbull
  • 通讯作者:
    M. Turnbull
Bolus Detection in the Proximal Esophagus Using Pulse-Echo Ultrasound: A Feasibility Study
使用脉冲回波超声检测近端食管的食团:可行性研究
  • DOI:
    10.1177/0194599820920835
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Andrew Wilcox;D. Jackson;Joshua Jones;Samuel Thomas
  • 通讯作者:
    Samuel Thomas
Cascaded Multilingual Audio-Visual Learning from Videos
视频级联多语言视听学习
  • DOI:
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Andrew Rouditchenko;Angie Boggust;David F. Harwath;Samuel Thomas;Hilde Kuehne;Brian Chen;Rameswar Panda;R. Feris;Brian Kingsbury;M. Picheny;James R. Glass
  • 通讯作者:
    James R. Glass
Transitioning shifting cultivation to resilient farming systems in South and Southeast Asia
南亚和东南亚将轮耕转向弹性农业系统
Measurement of liver microsomal cytochrome p450 (CYP2D6) activity using [O-methyl-14C]dextromethorphan.
使用 [O-methyl-14C] 右美沙芬测量肝微粒体细胞色素 p450 (CYP2D6) 活性。
  • DOI:
  • 发表时间:
    1994
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    A. D. Rodrigues;M. Kukulka;B. Surber;Samuel Thomas;J. Uchic;Gary Rotert;G. Michel;B. Thome;J. Machinist
  • 通讯作者:
    J. Machinist

Samuel Thomas的其他文献

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{{ truncateString('Samuel Thomas', 18)}}的其他基金

Collaborative Research: Accessing the Near Infrared Transparency Window for Triggered Delivery with Singlet Oxygen-Degradable Nanomaterials
合作研究:利用近红外透明窗口触发单线态氧可降解纳米材料的传递
  • 批准号:
    2003341
  • 财政年份:
    2020
  • 资助金额:
    $ 50万
  • 项目类别:
    Standard Grant
Photoinduced Charge-Shifting and Self-Assembly of Photochromic Polyelectrolytes
光致变色聚电解质的光致电荷转移和自组装
  • 批准号:
    1806263
  • 财政年份:
    2018
  • 资助金额:
    $ 50万
  • 项目类别:
    Standard Grant
Singlet Oxygen-Responsive Fluorescent Nanomaterials
单线态氧响应荧光纳米材料
  • 批准号:
    1609146
  • 财政年份:
    2016
  • 资助金额:
    $ 50万
  • 项目类别:
    Standard Grant
Multiplicative Amplification with Singlet Oxygen and Conjugated Polymers for Bioanalytical Applications
用于生物分析应用的单线态氧和共轭聚合物的倍增扩增
  • 批准号:
    1305832
  • 财政年份:
    2013
  • 资助金额:
    $ 50万
  • 项目类别:
    Continuing Grant

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