Implantable Self-Powered Biofeedback Vagus Nerve Stimulator for Weight Control

用于体重控制的植入式自供电生物反馈迷走神经刺激器

基本信息

  • 批准号:
    10801765
  • 负责人:
  • 金额:
    $ 43.98万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-09-25 至 2027-08-31
  • 项目状态:
    未结题

项目摘要

Project Summary Recent breakthroughs in neuromodulation for diet and weight control have stimulated a growing interest in the development of new anti-obesity strategies. However, achieving effective, real-time, and maintenance-free electrical neuromodulation with minimal side effects remains a major challenge. To address this challenge, this project proposes to develop a battery-free, flexible, and implantable piezoelectric nanogenerator (NG) that produces closed-loop, biofeedback electrostimulation (ES) on the vagus nerves to control food intake in response to stomach motions. This project builds on the collaborative work by Wang (PI) and Cai (co-I) of an implantable vagus nerve stimulation (VNS) device, which achieved effective diet and weight control in rats. The battery- and electronics-free VNS device is attached to the stomach surface and generates alternative current (AC) ES signals to the vagus nerves only when the stomach moves upon food intake. Our preliminary study demonstrated 38% less weight gain on normal adult rats with the VNS device implantation as compared to controls over a 100-day testing period. Although this efficacy value surpassed most peer reports, the ES signal intensity was 1-2 orders of magnitude smaller compared to those typically used. We hypothesize that tuning the closed-loop ES signal to the typical level of neuromodulation may further increase weight loss efficacy outperforming the currently-used non-natural continuous ES. To test this hypothesis and eventually bring this intriguing technology to clinic, we propose to develop a piezoelectric NG that provides tunable ES pulse signals up to 10 V in response to stomach peristalsis, and remains safe and stable over long- term implantation. We will also optimize the implantation of the VNS device and validate the closed-loop VNS efficacy and advantages to using standard obese rat models. In Specific Aim 1, we will develop a biomaterial- based flexible piezoelectric NGs that can produce tunable ES pulses in response to simulated stomach movements. In Specific Aim 2, we will evaluate the biocompatibility of the NG ex vivo and in vivo on the stomach of rats, and examine implantation sites and in vivo outputs in correlation to stomach motions. In Specific Aim 3, we will quantify and compare the diet and weight control performances on two obese rat models among three different strategies of using on-stomach NGs for VNS: (1) battery-powered open-loop VNS; (2) NG-enabled self- powered closed-loop VNS; (3) NG-switched battery-powered closed-loop VNS. This project will deliver a novel biomaterial-based VNS device that is battery- and electronics-free for weight control. This project uses rat model to test the new VNS devices, providing rapid feedback for device optimization, and quantifying the therapeutic efficacy in correlation to ES signals. Implantation-related technical issues will also be addressed. Together, we will establish an essential biological and engineering foundation that will allow us to move rapidly to the next step of in vivo studies in large animal models, eventually leading to human trials.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Xudong Wang其他文献

Xudong Wang的其他文献

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{{ truncateString('Xudong Wang', 18)}}的其他基金

Nanogenerator-Driven Self-Sustainable Power Source for Intracardiac Pacemakers
用于心内起搏器的纳米发电机驱动的自持续电源
  • 批准号:
    10615800
  • 财政年份:
    2021
  • 资助金额:
    $ 43.98万
  • 项目类别:
Nanogenerator-Driven Self-Sustainable Power Source for Intracardiac Pacemakers
用于心内起搏器的纳米发电机驱动的自持续电源
  • 批准号:
    10534064
  • 财政年份:
    2021
  • 资助金额:
    $ 43.98万
  • 项目类别:
Nanogenerator-Driven Self-Sustainable Power Source for Intracardiac Pacemakers
用于心内起搏器的纳米发电机驱动的自持续电源
  • 批准号:
    10415097
  • 财政年份:
    2021
  • 资助金额:
    $ 43.98万
  • 项目类别:
Nanogenerator-Driven Self-Sustainable Power Source for Intracardiac Pacemakers
用于心内起搏器的纳米发电机驱动的自持续电源
  • 批准号:
    10831936
  • 财政年份:
    2021
  • 资助金额:
    $ 43.98万
  • 项目类别:
Nanogenerator-Driven Self-Sustainable Power Source for Intracardiac Pacemakers
用于心内起搏器的纳米发电机驱动的自持续电源
  • 批准号:
    10182276
  • 财政年份:
    2021
  • 资助金额:
    $ 43.98万
  • 项目类别:
Membranous Nanogenerators for in vivo Bio-mechanical Energy Harvesting
用于体内生物机械能量收集的膜纳米发电机
  • 批准号:
    9418602
  • 财政年份:
    2016
  • 资助金额:
    $ 43.98万
  • 项目类别:
Membranous Nanogenerators for in vivo Bio-mechanical Energy Harvesting
用于体内生物机械能量收集的膜纳米发电机
  • 批准号:
    9977061
  • 财政年份:
    2016
  • 资助金额:
    $ 43.98万
  • 项目类别:
Membranous Nanogenerators for in vivo Bio-mechanical Energy Harvesting
用于体内生物机械能量收集的膜纳米发电机
  • 批准号:
    9266759
  • 财政年份:
    2016
  • 资助金额:
    $ 43.98万
  • 项目类别:

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