Ligand-Macromolecule Recognition: A Collaboration in Research and Education Between Vanderbilt and Leipzig Universities.

配体大分子识别：范德比尔特大学和莱比锡大学之间的研究和教育合作。

• 批准号: 1157751
• 负责人: Jens Meiler
• 金额: $ 6.99万
• 依托单位: Vanderbilt University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1157751&HistoricalAwards=false
• 关键词: Ligand; Macromolecule; Recognition; Collaboration; Research

Vanderbilt and Leipzig Universities in the area of Chemical Biology will establish a sustainable collaboration in education and research to study the fundamentals of ligand-macromolecule recognition by combining chemical tool compounds with biophysical techniques. The similar research foci of both institutions combined with complementary technologies will provide students and post-doctoral fellows with a comprehensive education. Jens Meiler of Vanderbilt University (VU) and Annette Beck-Sickinger of Leipzig University (LU) spearhead this initiative. Intellectual Merit: Although ligand-macromolecule recognition is at the core of biologicalprocesses, it is still poorly understood. LU offers basic science expertise with unique tool compoundssuch as carbaborane analogues, non-natural amino acid peptides, leading technology for expression of labeled human membrane proteins and solid-state NMR studies of such membrane proteins. This is complemented by VU?s translational science expertise in liquid-state NMR and EPR studies, a high-throughput screening facility to identify novel tool compounds, and computational modeling technologies unique for ligandmacromolecule recognition. The collaboration is further strengthened throughthe joint development of novel biochemical assays. Broader Impacts: This project will support a) planning visits, and b) exchange of students andpost-doctoral fellows on all levels. Four planning visits of Jens Meiler and five other VU faculty to LU inLeipzig, Germany will occur on an annual basis. During their stay the VU researchers will present at scientific symposia, participate in roundtable discussions, and meet with potential collaborators one-on-one. Technology exchange will befostered through tutorials offered by the faculty. The faculty will also develop and implement mentorshipplans for student exchanges. At least six research visits per year will involve the exchange and co-mentoringof students or post-doctoral fellows from VU. Participating in an international program, teachingand learning new ideas, publication of a scientific manuscript, and attending research seminars arecollectively experiences that are invaluable for a young scientist. Their participation in internationalexchange will broaden their perspectives, thus making them more competitive in their field. The studentswill share ideas and techniques with their collaborators, and similarly instruct their home laboratory withthe knowledge gained at LU. Additionally, their experiences will enhance applications to the ?InternationalResearch Fellowship Program? and ?Graduate Research Fellowship Program?. Exchange visits arecomplemented by a comprehensive set of off-site tools such as joint website (www.leipzig.vanderbilt.edu),project wiki pages to exchange data and tutorials, and video conferences. The proposal further involvesexchange of undergraduate students with focus on groups underrepresented in science leveraging thePI?s CAREER award undergraduate open house. The collaboration is mutually beneficial as it providesaccess to complementary knowledge and technologies. Researchers will travel in both directions: U.S.researchers supported through the present proposal, German researchers through grant support from theGerman Academic Exchange Service and the German Research Foundation.

范德比尔特大学和莱比锡大学将在化学生物学领域建立可持续的教育和研究合作，通过将化学工具化合物与生物物理技术相结合，研究配体-大分子识别的基础。两所院校相似的研究重点，结合互补的技术，将为学生和博士后提供全面的教育。范德比尔特大学（VU）的Jens Meiler和莱比锡大学（LU）的Annette Beck-Sickinger是这项倡议的先锋。知识价值：虽然配体-大分子识别是生物过程的核心，但人们对它的了解仍然很少。LU提供基础科学专业知识，独特的工具化合物，如碳水化合物类似物，非天然氨基酸肽，标记的人类膜蛋白表达的领先技术和这些膜蛋白的固态核磁共振研究。这是由VU？s在液态核磁共振和EPR研究方面的转化科学专业知识，用于识别新工具化合物的高通量筛选设施，以及用于配体大分子识别的独特计算建模技术。通过联合开发新的生化检测方法，进一步加强了合作。更广泛的影响：该项目将支持a)计划访问，b)各级学生和博士后研究员的交流。延斯·梅勒和其他五名VU教师计划每年访问德国莱比锡的LU。在他们逗留期间，VU研究人员将出席科学专题讨论会，参加圆桌讨论，并与潜在的合作者一对一会面。技术交流将通过教师提供的教程来促进。学院还将制定和实施学生交换的指导计划。每年至少有六次研究访问将涉及来自VU的学生或博士后研究员的交流和共同指导。参加一个国际项目，教授和学习新的思想，发表一篇科学手稿，参加研究研讨会，这些对一个年轻的科学家来说都是宝贵的回忆。他们参加国际交流将开阔他们的视野，从而使他们在各自的领域更有竞争力。学生们将与他们的合作者分享想法和技术，同样也会用在卢大学到的知识指导他们的家庭实验室。此外，他们的经验将增强对？国际研究奖学金计划？然后呢?研究生研究奖学金计划？交流访问还辅之以一套全面的非现场工具，如联合网站（www.leipzig.vanderbilt.edu）、交换数据和教程的项目wiki页面以及视频会议。该提案进一步涉及本科生交流，重点关注在科学领域代表性不足的群体。职业奖本科生开放日。这种合作是互利的，因为它提供了获得互补知识和技术的途径。研究人员将在两个方向旅行：美国研究人员通过本提案支持，德国研究人员通过德国学术交流服务和德国研究基金会的资助支持。