Genetic Instability at a Complex Gene Cluster in Arabidopsis

拟南芥复杂基因簇的遗传不稳定性

• 批准号: 1158297
• 负责人: Eric Richards
• 金额: $ 61.44万
• 依托单位: Boyce Thompson Institute Plant Research
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1158297&HistoricalAwards=false
• 关键词: Genetic; Instability; Complex; Gene; Cluster

Intellectual Merit:Flowering plants contain clusters of repeated genes, many of which are involved in recognition of pathogens. The structures of these genes are often highly variable and a combination of forces drives the diversification among repeated pathogen recognition genes. This project investigates a unique situation in the model flowering plant, Arabidopsis thaliana (mouse-ear cress), where the divergence between duplicated copies of a pathogen recognition gene called SNC1 is extremely rapid. The project focuses on this particular model to define the molecular mechanisms responsible for the frequent birth-and-death of pathogen resistance genes in plants.Broader Impacts:The project contains three different elements that broaden its impact. First, the research addresses fundamental questions regarding the ways that genetic change and rapid evolutionary processes occur. The results of the research will also provide insight into the forces that diversify a plant's arsenal of genes devoted to protection against agricultural pests. The second broader impact of the project will be the training and mentoring of scientists at the postdoctoral, graduate and undergraduate levels. Finally, the project directly engages high school students in the central New York region in an authentic collaborative research project, connecting these students, as well as their teachers, with scientists at the Boyce Thompson Institute.

智力优点：开花植物含有重复基因簇，其中许多与病原体的识别有关。 这些基因的结构通常高度可变，多种力量的结合推动了重复病原体识别基因的多样化。 该项目研究了模型开花植物拟南芥（鼠耳水芹）的独特情况，其中名为 SNC1 的病原体识别基因的重复拷贝之间的分歧非常快。 该项目重点关注这一特定模型，以定义导致植物中病原体抗性基因频繁产生和死亡的分子机制。更广泛的影响：该项目包含三个不同的要素，扩大了其影响。 首先，该研究解决了有关遗传变化和快速进化过程发生方式的基本问题。 研究结果还将深入了解使植物的基因库多样化的力量，这些基因致力于防止农业害虫。 该项目的第二个更广泛的影响将是对博士后、研究生和本科生科学家的培训和指导。 最后，该项目直接让纽约中部地区的高中生参与一个真实的合作研究项目，将这些学生及其老师与博伊斯汤普森研究所的科学家联系起来。