NSF NPGI Postdoctoral Fellowship in Biology FY 2012

2012 财年 NSF NPGI 生物学博士后奖学金

• 批准号: 1202793
• 负责人: Patrick Edger
• 金额: $ 19.71万
• 依托单位: Edger Patrick P
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1202793&HistoricalAwards=false
• 关键词: NSF; NPGI; Postdoctoral; Fellowship; Biology

This action funds a National Plant Genome Initiative Postdoctoral Research Fellowship for FY 2012. The fellowship supports a research and training plan in a host laboratory for the Fellow to focus their studies in plant genomics with an emphasis on quantitative genetics, modern breeding approaches, and bioinformatics. The title of the research and training plan for this fellowship to Patrick P. Edger is "Constructing Plant Metabolic Networks and a Comparative Framework to Identify Genes to Manipulate Biosynthetic Pathways in Crops". The host institution for the fellowship is the University of Arizona and the sponsoring scientists are Drs. Michael Barker (University of Arizona) and Michael Freeling (University of California - Berkeley). In order to begin addressing more complex questions in biology (e.g. elucidating genotype to phenotype relationships and plant-environmental interactions), the next phase of biology must involve integrating the wealth of diverse biological resources (e.g. sequenced genomes, gene expression data, protein data, and metabolic data) available to the scientific community. This study seeks to investigate how metabolic networks, the complete set of biochemical reactions in the cell (e.g. photosynthesis, respiration, and biosynthesis of defensive secondary metabolite compounds, have evolved over time (e.g. topology and content), to distinguish plastic portions from more conserved sections, and ultimately identify sub-networks that are more amenable to modification for crop improvement. Training objectives include bioinformatics, biochemistry, and plant genomics. Broader impacts include capacity-building and advanced training for students from the United States to engage in interdisciplinary research in plant improvement and associated sciences such as physiology, quantitative genetics, and computational biology. Outreach activities include the development of a visualization tool that will allow plant biologists to more easily analyze gene expression differences at the global network level and to calculate differences in metabolic costs. In addition the Fellow will be participate in introductory bioinformatics workshops that will train both undergraduate students and more advanced researchers in basic computer programming skills and in the use of available tools to analyze and interpret various datasets.

该行动为2012财年的国家植物基因组计划博士后研究奖学金提供资金。该研究金支持在一个宿主实验室的研究和培训计划，使研究员将研究重点放在植物基因组学上，重点是数量遗传学，现代育种方法和生物信息学。帕特里克P. Edger的研究和培训计划的标题是“构建植物代谢网络和比较框架，以确定操纵作物生物合成途径的基因”。 该研究金的主办机构是亚利桑那大学，赞助科学家是Michael Barker博士（亚利桑那大学）和Michael Freeling博士（加州大学-伯克利分校）。 为了开始解决生物学中更复杂的问题（例如阐明基因型与表型的关系以及植物与环境的相互作用），生物学的下一阶段必须涉及整合科学界可用的丰富的不同生物资源（例如测序的基因组，基因表达数据，蛋白质数据和代谢数据）。这项研究旨在研究代谢网络，细胞中的全套生化反应（例如光合作用，呼吸作用和防御性次级代谢产物化合物的生物合成）如何随着时间的推移而演变（例如拓扑结构和内容），以区分塑料部分和更保守的部分，并最终确定更适合作物改良的子网络。 培训目标包括生物信息学、生物化学和植物基因组学。 更广泛的影响包括为美国学生提供能力建设和高级培训，使他们能够从事植物改良和相关科学（如生理学、数量遗传学和计算生物学）的跨学科研究。 外联活动包括开发一个可视化工具，使植物生物学家能够更容易地分析全球网络一级的基因表达差异，并计算代谢成本的差异。 此外，研究员将参加介绍性生物信息学讲习班，这些讲习班将培训本科生和更高级的研究人员掌握基本的计算机编程技能，并使用现有工具分析和解释各种数据集。