Multifunctional Hybrid Porous Nanoparticles for Controlled Drug Release

ID：MPS/dmr/bmat(7623)1207019 PI：Weiss，Sharon ORG：Vanderbilt University标题：用于受控药物释放的多功能杂化多孔纳米颗粒技术优点：多孔硅(PSI)具有可调节的孔隙率、生物相容性、生物降解性和极大的比表面积，可用于载药和受控释放，是一种很有前途的药物输送载体。与脂质体或胶束药物输送载体不同，PSI可以通过PI最近开发的压印技术制造成各种尺寸和形状。这项建议的目的是探索多功能多孔微米和纳米颗粒用于治疗局部病理。这项研究的具体目标是：(1)了解多孔硅颗粒(PSP)的形状和大小对细胞摄取和选择性的影响，(2)研究智能表面附着化学，使负载的治疗性多肽能够在细胞内、特定部位释放，以及(3)探索超声诱导药物释放机制和压电功能化PSP的可行性。BROADER影响：这项研究结合了材料科学、生物医学工程、电气工程和物理学等互补学科的科学和工程方法，以实现能够对抗一些最具社会和经济破坏性的医疗疾病的药物输送平台。该计划的综合教育目标包括让参与的研究生和本科生研究人员接触纳米科学的跨学科性质和基于团队的研究氛围。研究团队成员的选择将强调增加性别和少数民族的参与，通过与NSF赞助的现有范德比尔特-菲斯克-特拉华州i-Cube材料科学计划、范德比尔特纳米科学和工程REU计划以及SWE、NSBE和SHPE的范德比尔特分会协调，促进这一点。K-12教育外联活动将侧重于开展以探究为基础的学习活动，传授纳米科学概念，并在学校访问和纳什维尔探险科学中心的活动期间分享。

ID: MPS/DMR/BMAT(7623) 1207019 PI: Weiss, Sharon ORG: Vanderbilt UniversityTitle: Multifunctional Hybrid Porous Nanoparticles for Controlled Drug ReleaseINTELLECTUAL MERIT: Porous silicon (PSi) is a promising drug delivery vehicle owing to its tunable porosity, biocompatibility, biodegradability, and exceptionally large specific surface area, which can be exploited for drug loading and controlled release. Unlike liposomal or micellar drug delivery vehicles, PSi can be fabricated into a vast range of sizes and shapes by an imprinting technique recently developed by the PI. The aim of this proposal is to explore multifunctional porous micro- and nanoparticles for the treatment of localized pathologies. The specific objectives of the research are: (1) understanding the impact of porous silicon particle (PSP) shape and size on cellular uptake and selectivity, (2) investigating smart surface attachment chemistries to enable intracellular, site-specific release of loaded therapeutic peptides, and (3) exploring the viability of an ultrasonically-induced drug release mechanism and piezoelectric-functionalized PSPs.BROADER IMPACTS: This research combines scientific and engineering methods of the complementary disciplines of materials science, biomedical engineering, electrical engineering, and physics for the realization of a drug delivery platform capable of combating some of the most socially and economically devastating medical conditions. The integrated educational goals of the plan involve the exposure of participating graduate and undergraduate researchers to the interdisciplinary nature of nanoscience and a team-based research atmosphere. Member selection of the research team will emphasize increasing the participation of gender and ethnic minorities, as facilitated through coordination with the existing NSF-sponsored Vanderbilt-Fisk-Delaware State I-cubed program in materials science, the Vanderbilt Institute of Nanoscale Science and Engineering REU program, and the Vanderbilt chapters of SWE, NSBE, and SHPE. Educational K-12 outreach will focus upon the development of inquiry-based learning activities to teach nanoscience concepts, to be shared during school visits and events at the Nashville Adventure Science Center.