Two-Dimensional Infrared Spectroscopy of the Conformational Dynamics of Biomolecules

生物分子构象动力学的二维红外光谱

• 批准号: 1212557
• 负责人: Andrei Tokmakoff
• 金额: $ 59.72万
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-15 至 2014-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1212557&HistoricalAwards=false
• 关键词: Two; Dimensional; Infrared; Spectroscopy; Conformational

In this award, funded by the Chemical Structure, Dynamics and Mechanism Program, Prof. Andrei Tokmakoff of the Chemistry Department of the Massachusetts Institute of Technology and his graduate student colleagues will develop ultrafast two-dimensional vibrational spectroscopy and use it in conjunction with nanosecond laser temperature-jumps to characterize the conformations of biomolecules and describe their conformational dynamics. These methods will be used to study the folding of NTL9. New methods for studying DNA G-quadruplexes will be developed. Besides the broader scientific impacts of the research being supported, the research students working on these projects will gain experience with advanced laser techniques. Prof. Tokmakoff also maintains a Web site(http://www.mit.edu/~tokmakof/TDQMS/) through which his most recent quantum mechanics course materials are made available. Additional lecture and laboratory course materials are distributed on the MIT OpenCourseWare Web site(http://ocw.mit.edu/OcwWeb/web/home/home/index.htm/).

在这个由化学结构，动力学和机制计划资助的奖项中，马萨诸塞州理工学院化学系的Andrei Tokmakoff教授和他的研究生同事将开发超快二维振动光谱，并将其与纳秒激光温度跳跃结合使用，以表征生物分子的构象并描述其构象动力学。这些方法将用于研究NTL 9的折叠。研究DNA G-四链体的新方法将被开发出来。除了支持研究的更广泛的科学影响外，从事这些项目的研究生还将获得先进激光技术的经验。Tokmakoff教授还维护一个网站（http：//www.mit.edu/tokmakof/TDQMS/），通过该网站可以获得他最近的量子力学课程材料。附加的讲座和实验室课程材料在麻省理工学院开放式课程网站（http：//ocw.mit.edu/OcwWeb/web/home/home/index.htm/）上分发。