Two-dimensional infrared spectroscopy of protein conformational dynamics

在这个由实验物理化学项目资助的奖项中，麻省理工学院化学系的Andrei Tokmakoff教授和他的研究生同事将开发酰胺和水振动的二维红外（2D IR）光谱，并将其与纳秒激光温度跳变相结合，研究蛋白质和肽的构象变化和动力学。除了所支持的研究的更广泛的科学影响外，从事这些项目的研究生将获得先进激光技术的经验。Tokmakoff教授还维护了一个网站（http://www.mit.edu/~tokmakof/TDQMS/），通过该网站可以获得他最新的量子力学课程材料。额外的讲座和实验课程材料可在麻省理工学院开放课程网站（http://ocw.mit.edu/OcwWeb/web/home/home/index.htm/）上找到。

In this award, funded by the Experimental Physical Chemistry Program, Prof. Andrei Tokmakoff of the Chemistry Department of the Massachusetts Institute of Technology and his graduate student colleagues will develop two dimensional infrared (2D IR) spectroscopy of amide and water vibrations, and use these in combination with nanosecond laser temperature-jumps to study protein and peptide conformational variation and dynamics. Besides the broader scientific impacts of the research being supported, the research students working on these projects will gain experience with advanced laser techniques. Prof. Tokmakoff also maintains a Web site(http://www.mit.edu/~tokmakof/TDQMS/) through which his most recent quantum mechanics course materials are made available. Additional lecture and laboratory course materials are distributed on the MIT OpenCourseWare Web site(http://ocw.mit.edu/OcwWeb/web/home/home/index.htm/).