权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

RUI-Effect of pH on Chiral Recognition of Amino Acid Based Micelles

RUI-pH 对氨基酸胶束手性识别的影响

基本信息

批准号：
1213532
负责人：
Fereshteh Billiot
金额：
$ 27.5万
依托单位：
Texas A&M University Corpus Christi
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-15 至 2016-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1213532&HistoricalAwards=false
关键词：
RUI Effect pH Chiral Recognition

项目摘要

In this award, funded by the Chemical Measurement and Imaging Program of the Division of Chemistry, Professor Fereshteh Billiot of Texas A & M University Corpus Christi and Professor Kevin Morris of Carthage College and their undergraduate student researchers will be supported to investigate the effect of pH on chiral recognition by amino acid derived surfactants towards other species. The effect of pH on these surfactants will be studied with solution-phase nuclear magnetic resonance (NMR) methods, combined with other physical characterization methods. The surfactants show promise as pseudo-stationary phases in capillary electrophoresis separations of chiral mixtures. Chiral molecules are molecules that have "handed" symmetry. They differ in structure from each other only in the sense that they are mirror images of each other. Since they have identical chemical structures, except for their handedness, mixtures of the chiral isomers are difficult to separate. Professors Billiot, Morris and their students are interested in designing new ways to separate chiral isomers. This work has important applications in purification and analysis of pharmaceuticals. The undergraduate students working on this project will gain useful experience in carrying out the physic-chemical characterization of these interesting surfactant systems. As part of this work, Prof. Billiot will continue her strong efforts at encouraging students from underrepresented groups to pursue careers in the sciences

该奖项由化学学部化学测量和成像项目资助，德克萨斯大学科Corpus Christi分校的Fereshteh Billiot教授和迦太基学院的Kevin Morris教授以及他们的本科生研究人员将获得资助，研究pH值对氨基酸衍生表面活性剂对其他物种手性识别的影响。pH值对这些表面活性剂的影响将通过溶液相核磁共振（NMR）方法结合其他物理表征方法进行研究。表面活性剂在手性混合物的毛细管电泳分离中具有良好的应用前景。手性分子是具有“手”对称的分子。它们在结构上的不同只是因为它们是彼此的镜像。由于它们具有相同的化学结构，除了它们的手性外，手性异构体的混合物很难分离。比略特教授、莫里斯教授和他们的学生对设计分离手性异构体的新方法很感兴趣。这项工作在药物的纯化和分析中有重要的应用。从事本项目的本科生将获得对这些有趣的表面活性剂体系进行物理化学表征的有用经验。作为这项工作的一部分，比洛特教授将继续努力鼓励来自代表性不足群体的学生从事科学事业