RUI-Effect of pH on Chiral Recognition of Amino Acid Based Micelles

在该奖项中，由化学部的化学测量和成像计划资助，德克萨斯A M大学科珀斯克里斯蒂分校的Fereshteh Billiot教授和迦太基学院的Kevin Morris教授及其本科生研究人员将获得支持，以研究pH值对氨基酸衍生表面活性剂对其他物种的手性识别的影响。 pH值对这些表面活性剂的影响将研究与溶液相核磁共振（NMR）的方法，结合其他物理表征方法。 这些表面活性剂在手性混合物的毛细管电泳分离中显示出作为伪固定相的前景。 手性分子是具有“手”对称性的分子。 它们在结构上彼此不同，只是因为它们是彼此的镜像。 由于它们具有相同的化学结构，除了它们的手性，手性异构体的混合物很难分离。 Billiot教授、Morris教授和他们的学生对设计分离手性异构体的新方法很感兴趣。 这项工作在药物的纯化和分析中有重要的应用。 从事该项目的本科生将在进行这些有趣的表面活性剂系统的物理化学表征方面获得有用的经验。 作为这项工作的一部分，Billiot教授将继续努力鼓励来自代表性不足群体的学生从事科学事业

In this award, funded by the Chemical Measurement and Imaging Program of the Division of Chemistry, Professor Fereshteh Billiot of Texas A & M University Corpus Christi and Professor Kevin Morris of Carthage College and their undergraduate student researchers will be supported to investigate the effect of pH on chiral recognition by amino acid derived surfactants towards other species. The effect of pH on these surfactants will be studied with solution-phase nuclear magnetic resonance (NMR) methods, combined with other physical characterization methods. The surfactants show promise as pseudo-stationary phases in capillary electrophoresis separations of chiral mixtures. Chiral molecules are molecules that have "handed" symmetry. They differ in structure from each other only in the sense that they are mirror images of each other. Since they have identical chemical structures, except for their handedness, mixtures of the chiral isomers are difficult to separate. Professors Billiot, Morris and their students are interested in designing new ways to separate chiral isomers. This work has important applications in purification and analysis of pharmaceuticals. The undergraduate students working on this project will gain useful experience in carrying out the physic-chemical characterization of these interesting surfactant systems. As part of this work, Prof. Billiot will continue her strong efforts at encouraging students from underrepresented groups to pursue careers in the sciences