High sensitivity ion sensitive field effect transistors for implantable miniature pH sensor

用于植入式微型 pH 传感器的高灵敏度离子敏感场效应晶体管

• 批准号: 519886-2017
• 负责人: Cui, Bo
• 金额: $ 1.47万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=648379
• 关键词: sensitivity; ion; sensitive; field; effect

As of recent reports released by the Centre for Disease Control and Health Canada, over 52 M surgeries are performed annually in North America. Of the 52M surgeries, around 3.1M surgeries are considered to be of high risk. One of the major complications that can happen following gastrointestinal surgeries is the leakage of bodily fluid into the peritoneal cavity (anastomotic leakage). Early diagnosis and management of anastomotic leakage is critical to decreasing the risk of morbidity and mortality from the surgeries performed. The most common medical practices nowadays to detect such abdominal post-operative complications is to use the patients' feedback, imaging techniques, blood tests, and nurse follow-ups to assess the patient's condition after the surgery. These methods, however, are subject to a number of problems, errors, biases and are inefficient economically. The supporting company NERv, is developing an implantable biochip with multiple biosensors (including pH sensor) capable of detecting post-operative complications in real-time. The current project aims to fabricate pH sensor based on ion-sensitive field effect transistor (ISFET), with improved sensitivity and signal-to-noise ratio by nano-patterning the gate area with about 10 nm structures. The fabrication method we will use includes electron beam lithography, metal island film self-formation, and self-assembly of di-block copolymers.

根据加拿大疾病控制和卫生中心最近发布的报告，北美每年进行超过5200万例手术。在5200万例手术中，约有310万例手术被认为是高风险手术。胃肠道手术后可能发生的主要并发症之一是体液泄漏到腹膜腔中（吻合口漏）。吻合口瘘的早期诊断和治疗对于降低手术的发病率和死亡率至关重要。现在检测这种腹部手术后并发症的最常见的医疗实践是使用患者的反馈、成像技术、血液测试和护士随访来评估患者在手术后的状况。然而，这些方法受到许多问题、错误、偏差的影响，并且在经济上效率低下。支持公司NERv正在开发一种具有多个生物传感器（包括pH传感器）的植入式生物芯片，能够实时检测术后并发症。目前的项目旨在制造基于离子敏感场效应晶体管（ISFET）的pH传感器，通过纳米图案化约10 nm结构的栅极区域来提高灵敏度和信噪比。我们将使用的制造方法包括电子束光刻，金属岛膜自形成，和自组装的二嵌段共聚物。