High sensitivity ion sensitive field effect transistors for implantable miniature pH sensor

点击翻译按钮获取中文摘要

As of recent reports released by the Centre for Disease Control and Health Canada, over 52 M surgeries are performed annually in North America. Of the 52M surgeries, around 3.1M surgeries are considered to be of high risk. One of the major complications that can happen following gastrointestinal surgeries is the leakage of bodily fluid into the peritoneal cavity (anastomotic leakage). Early diagnosis and management of anastomotic leakage is critical to decreasing the risk of morbidity and mortality from the surgeries performed. The most common medical practices nowadays to detect such abdominal post-operative complications is to use the patients' feedback, imaging techniques, blood tests, and nurse follow-ups to assess the patient's condition after the surgery. These methods, however, are subject to a number of problems, errors, biases and are inefficient economically. The supporting company NERv, is developing an implantable biochip with multiple biosensors (including pH sensor) capable of detecting post-operative complications in real-time. The current project aims to fabricate pH sensor based on ion-sensitive field effect transistor (ISFET), with improved sensitivity and signal-to-noise ratio by nano-patterning the gate area with about 10 nm structures. The fabrication method we will use includes electron beam lithography, metal island film self-formation, and self-assembly of di-block copolymers.