Light Induced Enantiospecific Chiral Transfer In Solution

溶液中的光诱导对映特异性手性转移

• 批准号: 1213880
• 负责人: Jayaraman Sivaguru
• 金额: $ 42.95万
• 依托单位: North Dakota State University Fargo
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-15 至 2016-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1213880&HistoricalAwards=false
• 关键词: Light; Induced; Enantiospecific; Chiral; Transfer

Based on the funding from Chemical Structure, Dynamics and Mechanism Program (CSDM) program, Prof. Sivaguru Jayaraman's group at the Department of Chemistry and Biochemistry, North Dakota State University, Fargo, ND will carry out studies pertaining to light induced enantiospecific chiral transfer in solution. Synthesizing chiral compounds with high stereoselectivity during light induced transformations provides an opportunity to develop sustainable strategies with minimal impact on the environment. As part of the investigation the PI will pursue new strategies for stereocontrol in photoreactions to gain a fundamental understanding of interaction of light with matter coupled with an intricate control over molecular reactivity, dynamics and non-bonding interactions to enhance stereoselectivity in the photoproducts.The project development plan seamlessly integrates scientific research, educational training, and public outreach. Students involved in the proposed investigations will learn both traditional techniques to characterize and evaluate asymmetric induction during enantiospecific phototransformations and modern spectroscopic methods and characterization techniques to assess excited state reactivity. The PI plans to engage local high school students through the PICNICS (Parents Involvement with Children, Nurturing Intellectual Curiosity in Science) outreach program that he has developed at North Dakota. The aim of the outreach program is to provide a cutting edge research environment to high school students there by encouraging them to look up to science and math as career paths.

在化学结构、动力学和机制项目（CSDM）的资助下，北达科他州立大学化学和生物化学系的Sivaguru Jayaraman教授小组将开展有关光诱导溶液中对端特异性手性转移的研究。在光诱导转化过程中合成具有高立体选择性的手性化合物为开发对环境影响最小的可持续策略提供了机会。作为研究的一部分，PI将寻求光反应中立体控制的新策略，以获得光与物质相互作用的基本理解，以及对分子反应性、动力学和非键相互作用的复杂控制，以增强光产物的立体选择性。项目发展计划将科学研究、教育培训和公众宣传无缝结合。参与拟议研究的学生将学习传统技术来表征和评估对映特异性光转化过程中的不对称诱导，以及现代光谱方法和表征技术来评估激发态反应性。PI计划通过他在北达科他州开发的PICNICS（父母与孩子的参与，培养对科学的求知欲）外展项目吸引当地高中生。拓展项目的目的是通过鼓励高中生将科学和数学作为职业道路，为他们提供一个前沿的研究环境。