Development of a Theoretical Basis for Modeling Disease Processes in Marine Invertebrates
海洋无脊椎动物疾病过程建模理论基础的发展
基本信息
- 批准号:1216220
- 负责人:
- 金额:$ 128.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-06-15 至 2016-11-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The general question of how epizootics are initiated and terminated in marine invertebrate populations and how this process is supported by transmission provides a basis for expanding the evaluation of marine disease outbreaks. Addressing this question requires development of a theoretical framework for disease transmission among invertebrates in marine systems. Such a framework will contribute to the general advancement of the understanding of the Ecology of Marine Infectious Diseases (EMID). This proposal outlines a combined experimental and modeling effort that will provide a general theory for marine invertebrate diseases. The model will be informed using Dermo disease, caused by Perkinsus marinus, in Eastern oysters (Crassostrea virginica), as an experimental system. However, the model will be applicable to all sessile or nearly sessile species whose movement is restricted to small scales (e.g. bivalves, gastropods, sea urchins, corals) and to a range of hydrodynamic regimes from estuaries to lagoons to coral reef tracts. This project is interdisciplinary and is integrated across several disciplines. The team has a unique mixture of expertise in molluscan pathology and epizootiology, genetics, and modeling of coastal and estuarine systems, disease processes and the genetic milieu, as well as a long history of successful collaborative research. By integrating our expertise across disciplines, this project promises to provide novel insights into the disease transmission process for infectious diseases that are poorly described by traditional susceptible-infected-resistant models built upon contact rates. This deficiency in modeling disease transmission is widespread across many taxa of sessile marine organisms. The project also responds to the recommendations in EMID workshops for the development of general frameworks for marine diseases that can be applied to specific systems and to understanding the determinants of transmission of diseases and the spread of pathogens by environmental factors. The results of this project will provide an important advancement in the theoretical basis for modeling diseases and disease transmission in marine systems. This project will contribute to the training of students and early career scientists in disciplines of genetics, pathology, genomics, and population and circulation modeling that is needed to solve many of the important problems associated with fisheries and marine coastal systems. Project results will be disseminated through scientific conferences, publication in the peer-review literature, and websites. Project results will be used in ongoing outreach efforts through a collaborative outreach program between the Department of STEM Education and the Center for Coastal Physical Oceanography at Old Dominion University. Additional outreach will be through the Partnership for the Delaware Estuary and the Bayshore Discovery Project, organizations engaged in public outreach for Delaware Bay.
关于动物流行病如何在海洋无脊椎动物种群中开始和终止以及传播如何支持这一过程的一般性问题,为扩大对海洋疾病暴发的评估提供了基础。要解决这个问题,就需要发展海洋系统中无脊椎动物之间疾病传播的理论框架。这样一个框架将有助于普遍增进对海洋传染病生态学的了解。该提案概述了一项结合实验和建模的努力,将为海洋无脊椎动物疾病提供一般理论。该模型将利用东方牡蛎(Crassostrea virginica)中由marinus Perkinsus引起的皮肤病作为实验系统。然而,该模型将适用于所有活动范围仅限于小尺度的无底或接近无底物种(例如双壳类、腹足类、海胆、珊瑚),以及从河口、泻湖到珊瑚礁带的一系列水动力机制。这个项目是跨学科的,是多个学科的综合。该团队在软体动物病理学和流行病学、遗传学、海岸和河口系统建模、疾病过程和遗传环境方面拥有独特的专业知识,以及长期成功的合作研究历史。通过整合我们跨学科的专业知识,该项目有望为传染病的疾病传播过程提供新的见解,而传统的基于接触率的易感-感染-抗性模型无法描述这些疾病。这种疾病传播模型的缺陷在许多无根海洋生物分类群中普遍存在。该项目还响应了海洋疾病管理方案讲习班的建议,即制定可适用于具体系统的海洋疾病总体框架,并了解疾病传播的决定因素和环境因素对病原体的传播。该项目的研究结果将为海洋系统疾病建模和疾病传播提供重要的理论基础。该项目将有助于在遗传学、病理学、基因组学、人口和循环模型等学科方面培训学生和早期职业科学家,这些学科是解决与渔业和海洋海岸系统有关的许多重要问题所必需的。项目结果将通过科学会议、同行评议文献和网站发布。项目成果将通过STEM教育部和老道明大学海岸物理海洋学中心之间的合作外展计划,用于正在进行的外展工作。其他的外联将通过特拉华河口伙伴关系和海湾发现项目,组织从事特拉华湾的公共外联。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Eileen Hofmann其他文献
Eileen Hofmann的其他文献
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{{ truncateString('Eileen Hofmann', 18)}}的其他基金
Collaborative Research: Reconstructing bottom water temperatures from bivalves on the continental shelf: Holocene history as a window to the future in the Mid-Atlantic
合作研究:重建大陆架双壳类底层水温:全新世历史是大西洋中部未来的窗口
- 批准号:
2202879 - 财政年份:2022
- 资助金额:
$ 128.01万 - 项目类别:
Standard Grant
Development and Implementation of Workshops to Facilitate Capacity in Ocean Circulation, Ecosystem and Management Strategy Evaluation Modeling
开发和实施研讨会以促进海洋环流、生态系统和管理战略评估建模的能力
- 批准号:
1745214 - 财政年份:2017
- 资助金额:
$ 128.01万 - 项目类别:
Standard Grant
Collaborative Research: Elucidating Environmental Controls of Productivity in Polynas and the Western Antarctic Peninsula
合作研究:阐明波里纳斯和南极西部半岛生产力的环境控制
- 批准号:
1643652 - 财政年份:2017
- 资助金额:
$ 128.01万 - 项目类别:
Standard Grant
IMBER IMBIZO-II: Support and Facilitation
IMBER IMBIZO-II:支持和便利
- 批准号:
1038800 - 财政年份:2010
- 资助金额:
$ 128.01万 - 项目类别:
Standard Grant
The Third GLOBEC Open Science Meeting: Support and Facilitation
第三届 GLOBEC 开放科学会议:支持和便利
- 批准号:
0850004 - 财政年份:2009
- 资助金额:
$ 128.01万 - 项目类别:
Standard Grant
Collaborative Research: Seasonal Evolution of Chemical and Biological Variability in the Ross Sea
合作研究:罗斯海化学和生物变化的季节演变
- 批准号:
0838948 - 财政年份:2009
- 资助金额:
$ 128.01万 - 项目类别:
Standard Grant
CNH: Collaborative Research: Climate Change and Responses in a Coupled Marine System
CNH:合作研究:耦合海洋系统中的气候变化和响应
- 批准号:
0908939 - 财政年份:2009
- 资助金额:
$ 128.01万 - 项目类别:
Standard Grant
Collaborative Research: Weddell seals as autonomous sensors of the winter oceanography of the Ross Sea
合作研究:威德尔海豹作为罗斯海冬季海洋学的自主传感器
- 批准号:
0838911 - 财政年份:2009
- 资助金额:
$ 128.01万 - 项目类别:
Standard Grant
Collaborative Research: GLOBEC Pan-regional Synthesis: End-to-end Energy Budgets in US-GLOBEC Regions
合作研究:GLOBEC 泛区域综合:美国-GLOBEC 区域的端到端能源预算
- 批准号:
0814584 - 财政年份:2008
- 资助金额:
$ 128.01万 - 项目类别:
Standard Grant
Collaborative Research: U.S. SO GLOBEC Synthesis and Modeling: Understanding Interactions Between Climate Warming, Gyre Dynamics and Western Antarctic Peninsula Ecosystem Respons
合作研究:美国 SO GLOBEC 综合和建模:了解气候变暖、环流动力学和南极半岛西部生态系统响应之间的相互作用
- 批准号:
0523254 - 财政年份:2006
- 资助金额:
$ 128.01万 - 项目类别:
Continuing Grant
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