Multimodal music training strategy to reverse maladaptive cortical reorganization associated with chronic tinnitus

多模式音乐训练策略逆转与慢性耳鸣相关的适应不良皮质重组

• 批准号: 206619499
• 负责人: Professor Dr.-Ing. Christo Pantev
• 金额: --
• 依托单位: Department of Integrative Physiology
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/206619499?language=en
• 关键词: Multimodal; music; training; strategy; reverse

The core aim of this project is the development and the behavioral and electrophysiological evaluationof an individually tailored, multimodal music training strategy for the treatment of tonal tinnitus. Astraining stimulus, we will utilize music, which will be generated by the patients themselves by means ofplaying piano. The generated music will be filtered in real-time (i.e. amongst others suppression of afrequency band that is centered at the individual tinnitus frequency) and listened to via headphonesduring the training. The individually modified music is intended to partly or fully reverse maladaptivecortical reorganization outcomes that underlie the tinnitus perception by means of the regional (i.e. inauditory cortex regions involved into tinnitus perception) strengthening of inhibitory neuronal networks.Due to the (i) multimodality of the training (i.e. simultaneous involvement of motor as well as differentsensory brain regions), the (ii) motivation (which can be expected because the patients will playfavorite music of their choice), and the (iii) attention that necessarily has to be focused on all involvedmodalities, we expect maximum training efficacy. By means of the inclusion of suitable control patientsgroups, the roles of the factors multimodality and attention for training efficacy will be investigated.Secondary objectives are (i) the analysis of auditory phantom perception-related (i.e. tonal tinnitus,Zwicker tone) spontaneous cortical activity, as well as (ii) the investigation of effects of tinnitus-focused attention on cortical activity by means of MEG.

该项目的核心目的是开发和行为和电生理评估，该评估是针对色调耳鸣的单独量身定制的多模式音乐训练策略。我们将利用刺激刺激，我们将通过弹奏钢琴来由患者本身产生的音乐。生成的音乐将被实时过滤（即，以及其他以单个耳鸣频率为中心的狂热频段的抑制），并通过耳机聆听训练。单独修改的音乐旨在部分或全面反向疾病的疾病重组结果，这些结果是通过区域（即无审核性皮层区域中涉及的细胞核感知）来构成耳鸣感知的基础的，涉及抑制性神经元网络的增强（i）及其及（I）及（I）的培训（即I），即（i）及其及其培训（即I），即均与（i）相同的培训（I）。大脑区域），（ii）动机（可以预期，因为患者会选择他们选择的音乐），以及（iii）的注意力必定必须集中在所有涉​​及的模样上，我们期望最大的培训功效。通过包含合适的对照患者组，将研究因素多模式和注意力的因素的作用。中等目标是（i）（i）对听觉幻影知觉相关的分析（即，与tonal Tinnitus，Tonal Tinnitus，Zwicker Tone，Zwicker tone）通过（Zwicker tone）通过（Zwicker tone）通过（Zwicker tone）通过（Zwicker tone）通过自发性皮质活性，以及​​（II）的效果。梅格。