Multimodal music training strategy to reverse maladaptive cortical reorganization associated with chronic tinnitus

多模式音乐训练策略逆转与慢性耳鸣相关的适应不良皮质重组

• 批准号: 206619499
• 负责人: Professor Dr.-Ing. Christo Pantev
• 金额: --
• 依托单位: Department of Integrative Physiology
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/206619499?language=en
• 关键词: Multimodal; music; training; strategy; reverse

The core aim of this project is the development and the behavioral and electrophysiological evaluationof an individually tailored, multimodal music training strategy for the treatment of tonal tinnitus. Astraining stimulus, we will utilize music, which will be generated by the patients themselves by means ofplaying piano. The generated music will be filtered in real-time (i.e. amongst others suppression of afrequency band that is centered at the individual tinnitus frequency) and listened to via headphonesduring the training. The individually modified music is intended to partly or fully reverse maladaptivecortical reorganization outcomes that underlie the tinnitus perception by means of the regional (i.e. inauditory cortex regions involved into tinnitus perception) strengthening of inhibitory neuronal networks.Due to the (i) multimodality of the training (i.e. simultaneous involvement of motor as well as differentsensory brain regions), the (ii) motivation (which can be expected because the patients will playfavorite music of their choice), and the (iii) attention that necessarily has to be focused on all involvedmodalities, we expect maximum training efficacy. By means of the inclusion of suitable control patientsgroups, the roles of the factors multimodality and attention for training efficacy will be investigated.Secondary objectives are (i) the analysis of auditory phantom perception-related (i.e. tonal tinnitus,Zwicker tone) spontaneous cortical activity, as well as (ii) the investigation of effects of tinnitus-focused attention on cortical activity by means of MEG.

该项目的核心目标是开发和行为和电生理评估一个个性化的，多模式的音乐训练策略，用于治疗音调性耳鸣。我们将利用音乐来抑制刺激，这种音乐将由患者自己通过弹奏钢琴来产生。所产生的音乐将被实时过滤（即，除其他外，以个人耳鸣频率为中心的音频带的抑制），并在训练期间通过耳机收听。单独修改的音乐旨在部分或完全逆转适应不良的皮质重组结果，该结果是通过区域性的听觉刺激来引起耳鸣感知的基础。（即参与耳鸣感知的非听觉皮层区域）加强抑制性神经元网络。由于（i）训练的多模态（即同时涉及运动以及不同的感觉脑区），（ii）动机（这是可以预期的，因为患者会播放他们选择的最喜欢的音乐），以及（iii）必须集中在所有相关模式上的注意力，我们期望最大的训练功效。通过纳入合适的对照患者组，多模态和注意力因素对训练效果的作用将被调查，次要目标是（i）分析与听觉幻象感知相关的（即音调性耳鸣，Zwicker音）自发皮层活动，以及（ii）通过MEG调查耳鸣集中注意力对皮层活动的影响。