Support for the 2nd Penn State Bioinorganic Workshop

支持第二届宾夕法尼亚州立大学生物无机研讨会

• 批准号: 1216472
• 负责人: Carsten Krebs
• 金额: $ 1.52万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-01 至 2013-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1216472&HistoricalAwards=false
• 关键词: Support; 2nd; Penn; State; Bioinorganic

Intellectual Merit The 2nd Penn State Bioinorganic Workshop will be held on the University Park campus of The Pennsylvania State University from May 31-June 9, 2012. The proposed workshop aims to provide a complete immersion training experience to students and postdocs. The field of bioinorganic chemistry is diverse, and includes a wide variety of scientific disciplines, including genetics, molecular biology, biochemistry, bioinformatics, analytical chemistry, and physical chemistry. The workshop will include lecture topics, such as, (1) principles of molecular biology; (2) principles of coordination chemistry; (3) principles of quantum chemistry; (4) transient state kinetic methods; (5) EPR spectroscopy; (6) ENDOR/ESEEM spectroscopy; (7) computation of spectroscopic parameters; (8) resonance Raman spectroscopy; (9) X-ray absorption spectroscopy; (10) Mössbauer spectroscopy; (11) magnetic circular dichroism spectroscopy); (12) mass spectrometry; (13) isotope effects as mechanistic probes; (14) protein electrochemistry; (15) X-ray crystallography; and (16) biological electron transfer. In addition, a "hands-on" laboratory training aspect is also included. The following hands-on sessions will be offered: (1) SF-absorption spectroscopy; (2) the FQ method; (3) EPR spectroscopy; (4) Mössbauer spectroscopy; (5) ENDOR/ESEEM spectroscopy; (6) resonance Raman spectroscopy; (7) mass spectrometry ; (8) purification of air-sensitive enzymes; (9) site-directed mutagenesis; (10) protein electrochemistry; and (11) cryoreduction experiments at the Breazeale Nuclear Reactor on the Penn State campus. Broader ImpactsMany areas of this meeting will directly relate to central challenges facing society today. Fundamental collaborative research in bioinorganic chemistry may provide important insight for rational design of chemical/industrial processes. An example includes the improvement of the Haber Bosch process, a crucial process for modern agriculture, by a better understanding of the enzyme nitrogenase.This workshop will make important contributions to training of students and postdocs in bioinorgranics. Approximately 80 young researchers will immerse themselves in a wide variety of methods and concepts central to this research area, thus receiving training that will undoubtedly be broader than they could possibly receive in any one research group.

第二届宾夕法尼亚州立大学生物无机研讨会将于2012年5月31日至6月9日在宾夕法尼亚州立大学大学公园校区举行。该工作坊旨在为学生和博士后提供完整的浸入式训练体验。生物无机化学的领域是多样的，包括各种各样的科学学科，包括遗传学、分子生物学、生物化学、生物信息学、分析化学和物理化学。研讨会将包括讲座主题，例如：(1)分子生物学原理；(2)配位化学原理；(3)量子化学原理；(4)瞬态动力学方法；(5) EPR光谱；(6) ENDOR/ESEEM光谱；(7)光谱参数计算；(8)共振拉曼光谱；(9) x射线吸收光谱；（10） Mössbauer光谱；（11）磁圆二色光谱；（12）质谱分析；（13）同位素效应作为机制探针；（14）蛋白质电化学；（15） x射线晶体学；（16）生物电子转移。此外，“动手”实验室培训方面也包括在内。将提供以下实践课程：(1)sf吸收光谱；(2) FQ法；(3) EPR光谱；(4) Mössbauer光谱；(5) ENDOR/ESEEM光谱；(6)共振拉曼光谱；(7)质谱分析；(8)空气敏感酶的纯化；(9)定点诱变；（10）蛋白质电化学；（11）在宾夕法尼亚州立大学校园的布雷泽尔核反应堆进行的减冷实验。更广泛的影响本次会议的许多领域将直接涉及当今社会面临的主要挑战。生物无机化学的基础合作研究可以为化学/工业过程的合理设计提供重要的见解。一个例子包括通过更好地了解氮酶对现代农业至关重要的哈伯-博世工艺的改进。本次研讨会将为培养生物有机学专业的学生和博士后做出重要贡献。大约80名年轻的研究人员将沉浸在这一研究领域的各种方法和核心概念中，因此接受的培训无疑将比他们在任何一个研究小组所能接受的更广泛。