Support for the 2nd Penn State Bioinorganic Workshop

第二届宾夕法尼亚州立大学生物无机研讨会将于2012年5月31日至6月9日在宾夕法尼亚州立大学的大学园区举行。拟议的研讨会旨在为学生和博士后提供完整的沉浸式培训体验。生物无机化学领域是多样化的，包括广泛的科学学科，包括遗传学、分子生物学、生物化学、生物信息学、分析化学和物理化学。讲座主题包括：(1)分子生物学原理；(2)配位化学原理；(3)量子化学原理；(4)暂态动力学方法；(5)EPR光谱；(6)Endor/ESEEM光谱；(7)光谱参数的计算；(8)共振拉曼光谱；(9)X射线吸收光谱；(10)穆斯堡尔光谱；(11)磁圆二色谱；(12)质谱学；(13)作为机械探针的同位素效应；(14)蛋白质电化学；(15)X射线结晶学；(16)生物电子转移。此外，还包括“动手”实验室培训方面。将提供下列实践课程：(1)SF-吸收光谱；(2)FQ方法；(3)EPR光谱；(4)穆斯堡尔光谱；(5)Endor/ESEEM光谱；(6)共振拉曼光谱；(7)质谱学；(8)空气敏感酶的纯化；(9)定点突变；(10)蛋白质电化学；(11)在宾夕法尼亚州立大学Breazeale核反应堆的低温还原实验。更广泛的影响这次会议的许多领域将直接涉及当今社会面临的核心挑战。生物无机化学的基础合作研究可能为化学/工业过程的合理设计提供重要的启示。例如，通过更好地了解酶固氮酶，改进了现代农业的关键工艺哈伯博世工艺。这次研讨会将对学生和博士后进行生物无机物培训做出重要贡献。大约80名年轻研究人员将沉浸在这一研究领域核心的各种方法和概念中，因此接受的培训无疑将比他们在任何一个研究小组中可能接受的培训都要广泛。

Intellectual Merit The 2nd Penn State Bioinorganic Workshop will be held on the University Park campus of The Pennsylvania State University from May 31-June 9, 2012. The proposed workshop aims to provide a complete immersion training experience to students and postdocs. The field of bioinorganic chemistry is diverse, and includes a wide variety of scientific disciplines, including genetics, molecular biology, biochemistry, bioinformatics, analytical chemistry, and physical chemistry. The workshop will include lecture topics, such as, (1) principles of molecular biology; (2) principles of coordination chemistry; (3) principles of quantum chemistry; (4) transient state kinetic methods; (5) EPR spectroscopy; (6) ENDOR/ESEEM spectroscopy; (7) computation of spectroscopic parameters; (8) resonance Raman spectroscopy; (9) X-ray absorption spectroscopy; (10) Mössbauer spectroscopy; (11) magnetic circular dichroism spectroscopy); (12) mass spectrometry; (13) isotope effects as mechanistic probes; (14) protein electrochemistry; (15) X-ray crystallography; and (16) biological electron transfer. In addition, a "hands-on" laboratory training aspect is also included. The following hands-on sessions will be offered: (1) SF-absorption spectroscopy; (2) the FQ method; (3) EPR spectroscopy; (4) Mössbauer spectroscopy; (5) ENDOR/ESEEM spectroscopy; (6) resonance Raman spectroscopy; (7) mass spectrometry ; (8) purification of air-sensitive enzymes; (9) site-directed mutagenesis; (10) protein electrochemistry; and (11) cryoreduction experiments at the Breazeale Nuclear Reactor on the Penn State campus. Broader ImpactsMany areas of this meeting will directly relate to central challenges facing society today. Fundamental collaborative research in bioinorganic chemistry may provide important insight for rational design of chemical/industrial processes. An example includes the improvement of the Haber Bosch process, a crucial process for modern agriculture, by a better understanding of the enzyme nitrogenase.This workshop will make important contributions to training of students and postdocs in bioinorgranics. Approximately 80 young researchers will immerse themselves in a wide variety of methods and concepts central to this research area, thus receiving training that will undoubtedly be broader than they could possibly receive in any one research group.